Abstract An improved sonochemical condensation has been reported between chloro-substituted hydroxyl chalcones and hydrazine hydrate in 2-ethoxy ethanol as an efficient & alternative reaction medium in presence of sodium acetate and acetic acid to afford 2-pyrazolines. The pyrazolines were obtained in good to excellent yields (80-90%), and were characterized by conventional spectral data and evaluated for their antimicrobial potential. It is observed that the work-up is simple and the results obtained indicate that, unlike classical heating, ultrasound irradiation results in higher yields, shorter reaction times (1.5-2.5h) and milder reaction conditions. The investigation of antimicrobial potential revealed that all the synthesized compounds shows good to moderate growth inhibiting effect against microorganism tested.

中文翻译：

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羟基查尔酮在 2-乙氧基乙醇作为绿色反应介质中的高效超声诱导闭环和抗菌潜力研究

摘要 据报道，氯取代的羟基查耳酮和水合肼在 2-乙氧基乙醇中进行了一种改进的声化学缩合，作为一种有效的替代反应介质，在乙酸钠和乙酸存在下，得到 2-吡唑啉。吡唑啉以良好到极好的产率 (80-90%) 获得，并通过常规光谱数据进行表征并评估其抗菌潜力。据观察，后处理很简单，获得的结果表明，与传统加热不同，超声辐射导致更高的产率、更短的反应时间（1.5-2.5 小时）和更温和的反应条件。抗菌潜力的研究表明，所有合成的化合物对所测试的微生物都显示出良好到中等的生长抑制作用。