A novel library of sulphonamide derivatives of benzofuran-imidazopyridines (9a-j) were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by employing MTT assay. The results are expressed with IC₅₀ µM, which indicated that all of the compounds showed good to moderate activity on tested cell lines. Among them, compound 9c showed potent anticancer activities against MCF-7, A549, Colo-205 and A2780 cell lines with IC₅₀ values of 0.011 ± 0.0075 µM, 0.073 ± 0.0012 µM, 0.10 ± 0.19 µM and 0.034 ± 0.0041 µM respectively.

设计，合成并筛选了苯并呋喃-咪唑并吡啶（9a-j）的磺酰胺衍生物新文库，它们针对四种人类癌细胞系（例如乳腺癌（MCF-7），肺癌（A549），结肠癌（采用MTT分析法检测Colo-205）和卵巢癌（A2780）。结果用IC ₅₀ µM表示，表明所有化合物对受试细胞系均显示出良好至中等的活性。其中，化合物9c对MCF-7，A549，Colo-205和A2780细胞系显示有效的抗癌活性，IC ₅₀值分别为0.011±0.0075 µM，0.073±0.0012 µM，0.10±0.19 µM和0.034±0.0041 µM。