The detrimental qualitative and quantitative alterations of circulating endothelial progenitor cells in patients with bronchiectasis,Respiratory Medicine

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The detrimental qualitative and quantitative alterations of circulating endothelial progenitor cells in patients with bronchiectasis
Respiratory Medicine ( IF 4.3 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.rmed.2020.106270
Yangli Liu ₁ , Xinyan Huang ₁ , Dubo Chen ₂ , Fengjia Chen ₁ , Chengqiang Mo ₃ , Yubiao Guo ₁ , Canmao Xie ₁ , Gexiu Liu ₄ , Haitao Zeng ₅ , Yunwei Sun ₆ , Zhen Yang ₇

Affiliation

Background

Bronchiectasis is an independent risk factor for cardiovascular disease（CVD）and cardiac dysfunction. Endothelial progenitor cells (EPCs) play a crucial role in maintaining endothelial function, and is inversely correlated with cardiovascular risk factors or cardiac dysfunction. However, the relationship between EPCs and bronchiectasis is unknown.

Methods

Twenty-nine patients with stable bronchiectasis and 15 healthy controls were recruited. Fasting venous blood were collected for determining circulating EPC number and activity as well as systemic inflammatory cytokines.

Results

The number and migratory or proliferative activity of circulating EPCs in bronchiectasis patients were significantly reduced (p < 0.001). In high E-FACED group, the number of circulating EPCs evaluated by cell culture assay and EPC proliferation were decreased (p < 0.05). Similarly, the number and function of circulating EPCs were both reduced in low forced expiratory volume in 1 s (FEV1) or high mMRC group (p < 0.05). There was a significant correlation between circulating EPCs and bronchiectasis disease severity, according to the E-FACED score (p < 0.05), particularly to FEV1 (p < 0.05) and mMRC dyspnea score (p < 0.05). The count and activity of EPCs inversely correlated with hsCRP levels and IL-6 levels (p < 0.01).

Conclusions

Deficiencies in the number and function of circulating EPCs are present in patients with bronchiectasis. The changes are related to disease severity and may be partly attributed to systemic inflammation. The current findings may provide novel surrogate evaluation biomarkers and potential therapeutic target for bronchiectasis.

中文翻译：

支气管扩张患者循环内皮祖细胞的有害定性和定量改变

背景

支气管扩张是心血管疾病（CVD）和心功能不全的独立危险因素。内皮祖细胞 (EPCs) 在维持内皮功能方面起着至关重要的作用，并且与心血管危险因素或心脏功能障碍呈负相关。然而，EPCs 与支气管扩张之间的关系尚不清楚。

方法

招募了 29 名稳定的支气管扩张患者和 15 名健康对照者。收集空腹静脉血以确定循环 EPC 数量和活性以及全身炎症细胞因子。

结果

支气管扩张患者中循环 EPC 的数量和迁移或增殖活性显着降低（p < 0.001）。在高 E-FACED 组中，通过细胞培养测定和 EPC 增殖评估的循环 EPC 数量减少（p < 0.05）。类似地，循环 EPC 的数量和功能在 1 秒内用力呼气量低（FEV1）或高 mMRC 组（p < 0.05）中均减少。根据 E-FACED 评分 (p < 0.05)，尤其是 FEV1 (p < 0.05) 和 mMRC 呼吸困难评分 (p < 0.05)，循环 EPC 与支气管扩张疾病严重程度之间存在显着相关性。EPC 的数量和活性与 hsCRP 水平和 IL-6 水平呈负相关（p < 0.01）。