The aim of the present systematic review and meta-analysis was to assess the incidence of severe ovarian hyperstimulation syndrome (OHSS) after triggering of final oocyte maturation with gonadotrophin releasing hormone agonist (GnRHa) in high-risk women. The pooled incidence of severe OHSS in high-risk women who did not receive any form of luteal phase support was 0% (95% CI 0.0 to 0.0, I² = 0%, random-effects model, 14 data sets, 983 women). The pooled incidence of severe OHSS in high-risk women in whom HCG was added to standard luteal phase support was 1% (95% CI 0.0 to 2.0, I² = 27.02%, random-effects model, 10 data sets, 707 women). The incidence of severe OHSS in high-risk women triggered by a combination of GnRHa and HCG (dual triggering), who received standard luteal phase support, was 1% (95% CI 0.0 to 3.0, one study, 182 women). The incidence of severe OHSS in high-risk women, is not eliminated when HCG is administered either concomitantly with GnRHa (dual triggering), during the luteal phase after GnRHa triggering, or both. On the contrary, it is eliminated when no luteal support is administered.

本系统评价和荟萃分析的目的是评估高危女性在用促性腺激素释放激素激动剂 (GnRHa) 触发最终卵母细胞成熟后严重卵巢过度刺激综合征 (OHSS) 的发生率。在未接受任何形式的黄体期支持的高危女性中，严重 OHSS 的合并发生率为 0%（95% CI 0.0 至 0.0，I ²  = 0%，随机效应模型，14 个数据集，983 名女性） . 在标准黄体期支持中添加 HCG 的高危女性中，严重 OHSS 的合并发生率为 1%（95% CI 0.0 至 2.0，I ² = 27.02%，随机效应模型，10 个数据集，707 名女性）。在接受标准黄体期支持的高危女性中，由 GnRHa 和 HCG（双重触发）引发的严重 OHSS 的发生率为 1%（95% CI 0.0 至 3.0，一项研究，182 名女性）。当 HCG 与 GnRHa（双重触发）同时使用、在 GnRHa 触发后的黄体期期间或两者同时使用时，高危女性严重 OHSS 的发生率并不能消除。相反，当不给予黄体支持时，它会被消除。