Magnetic molecularly imprinted polymers (MIPs) have been synthesized for the removal of sulfanilamide as a major impurity in the sulfacetamide eye drops. In this study, the magnetic nanoparticles were modified by tetraethyl orthosilicate and 3-methacryloxypropyl trimethoxysilane before imprinting. The magnetic MIPs were prepared through surface molecular imprinting technique, by using Fe3O4 as a magnetic component, sulfanilamide as template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and 2,2-azobisisobutyronitrile as a radical initiator in acetonitrile/toluene (60:40, v/v) as a porogen. The obtained sorbent was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The selectivity of MIPs for the sulfanilamide impurity absorption was evaluated through adsorption experiments, and the results were compared to the adsorption of impurities by MIPs. Various parameters were optimized including the time, pH, and type of eluent used for the removal of impurities from polymer, concentration of sample, and saturation of polymer. The proposed method was applied to the removal of sulfanilamide from sulfacetamide eye drops. Passing the eye drops through the MIPs led to the quantitative removal of sulfanilamide.

中文翻译：

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磁性分子印迹聚合物在去除眼药水中主要杂质磺胺（磺胺）中的应用

磁性分子印迹聚合物 (MIP) 已被合成用于去除磺胺类药物作为磺胺醋酰胺滴眼液中的主要杂质。在这项研究中，磁性纳米粒子在压印前用原硅酸四乙酯和 3-甲基丙烯酰氧基丙基三甲氧基硅烷改性。以Fe3O4为磁性组分，磺胺为模板分子，甲基丙烯酸为功能单体，乙二醇二甲基丙烯酸酯为交联剂，2,2-偶氮二异丁腈为自由基引发剂，通过表面分子印迹技术制备磁性MIPs在乙腈/甲苯 (60:40, v/v) 中作为致孔剂。通过扫描电子显微镜和傅里叶变换红外光谱对所得吸附剂进行表征。通过吸附实验评估了 MIPs 对磺胺杂质吸附的选择性，并将结果与​​ MIPs 对杂质的吸附进行了比较。优化了各种参数，包括时间、pH 值和用于从聚合物中去除杂质的洗脱液类型、样品浓度和聚合物饱和度。所提出的方法用于从磺胺醋酰胺滴眼液中去除磺胺。将滴眼液通过 MIP 导致磺胺的定量去除。所提出的方法用于从磺胺醋酰胺滴眼液中去除磺胺。将滴眼液通过 MIP 导致磺胺的定量去除。所提出的方法用于从磺胺醋酰胺滴眼液中去除磺胺。将滴眼液通过 MIP 导致磺胺的定量去除。