Aseries of diethyl esters of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylic acids (β-cycloketols) were synthesized by Knoevenagel condensation. A method for their dehydration was developed. Peculiarities of the condensation depending on the reaction conditions were pointed out. All obtained cycloketols and some dehydrated analogs exhibited more or less pronounced anticonvulsant activity in the corazole seizure test in mice.

中文翻译：

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部分环己酮衍生物的合成及抗惊厥活性-Knoevenagel缩合物

通过 Knoevenagel 缩合合成了一系列 2-芳基-4-羟基-4-甲基-6-氧代环己烷-1,3-二羧酸（β-环酮醇）的二乙酯。开发了一种脱水方法。指出了取决于反应条件的缩合特性。所有获得的环酮醇和一些脱水类似物在小鼠考唑癫痫试验中或多或少表现出明显的抗惊厥活性。