We studied the selective formation of 3,5- and 2,5-pyrazinone via a transamidation-cyclization reaction. The equilibrium between acyl amides changed depending on the solvent, acidity, and substituents. Furthermore, selective transformation of 2,5-pyrazinone was accomplished by using a substrate with a secondary amine.

中文翻译：

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分子内酰胺化-环化

我们研究了通过氨基转移环化反应选择性形成3,5-和2,5-吡嗪酮。酰基酰胺之间的平衡根据溶剂，酸度和取代基而变化。此外，通过使用具有仲胺的底物来完成2，5-吡嗪酮的选择性转化。