Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involved in a variety of human malignant tumours. However, little is known about their expression and prognostic value in human pancreatic cancer. Therefore, we performed a detailed cancer versus normal differential analysis. The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases were used to analyse the mRNA expression levels of the IGF2BP family in various cancers, including pancreatic cancer. Then, the LinkedOmics and GEPIA databases were used to assess the relation between the expression levels of IGF2BPs and overall survival (OS). Then, univariate and multivariate Cox regression analyses were performed, and subgroups based on grade and stage were analysed. The signalling pathways associated with IGF2BP2 and IGF2BP3 were then investigated via gene set enrichment analysis (GSEA). IGF2BP2 and IGF2BP3 were associated with each subset of OS based on grade and stage. Further clinical correlation analysis of IGF2BP2 and IGF2BP3 confirmed that IGF2BP2 and IGF2BP3 are fundamental factors in promoting pancreatic cancer progression. IGF2BP2 and IGF2BP3 are key factors in promoting the progression of pancreatic cancer and are closely related to overall survival.

中文翻译：

---

胰岛素样生长因子2 mRNA结合蛋白家族在人胰腺癌中的表达及预后分析


尽管早期诊断和治疗取得了进步，癌症仍然是全世界死亡的主要原因。据报道，胰岛素样生长因子 2 mRNA 结合蛋白 (IGF2BP) 家族与多种人类恶性肿瘤有关。然而，人们对它们在人类胰腺癌中的表达和预后价值知之甚少。因此，我们进行了详细的癌症与正常差异分析。癌症基因组图谱 (TCGA) 和基因表达谱交互分析 (GEPIA) 数据库用于分析各种癌症（包括胰腺癌）中 IGF2BP 家族的 mRNA 表达水平。然后，使用 LinkedOmics 和 GEPIA 数据库评估 IGF2BP 的表达水平与总生存期 (OS) 之间的关系。然后，进行单变量和多变量 Cox 回归分析，并分析基于年级和分期的亚组。然后通过基因集富集分析 (GSEA) 研究与 IGF2BP2 和 IGF2BP3 相关的信号通路。 IGF2BP2 和 IGF2BP3 与基于分级和分期的每个 OS 子集相关。 IGF2BP2和IGF2BP3的进一步临床相关性分析证实IGF2BP2和IGF2BP3是促进胰腺癌进展的根本因素。 IGF2BP2和IGF2BP3是促进胰腺癌进展的关键因素，与总生存期密切相关。