The pandemic of Coronavirus Disease 2019 (COVID-19) presents the world with the medical challenge associated with multifactorial nature of this pathology. Indeed COVID-19 affects several organs and systems and presents diversified clinical picture. COVID-19 affects the brain in many ways including direct infection of neural cells with SARS-CoV-2, severe systemic inflammation which floods the brain with pro-inflammatory agents thus damaging nervous cells, global brain ischaemia linked to a respiratory failure, thromboembolic strokes related to increased intravascular clotting and severe psychological stress. Often the COVID-19 is manifested by neurological and neuropsychiatric symptoms that include dizziness, disturbed sleep, cognitive deficits, delirium, hallucinations and depression. All these indicate the damage to the nervous tissue which may substantially increase the incidence of neurodegenerative diseases and promote dementia.

中文翻译：

---

COVID-19 大流行会加剧神经退行性疾病的流行吗？


2019 年冠状病毒病 (COVID-19) 的大流行给世界带来了与这种病理学的多因素性质相关的医学挑战。事实上，COVID-19 会影响多个器官和系统，并呈现多样化的临床表现。 COVID-19 以多种方式影响大脑，包括 SARS-CoV-2 直接感染神经细胞、严重的全身性炎症（使大脑充满促炎剂从而损害神经细胞）、与呼吸衰竭相关的全脑缺血、血栓栓塞性中风与血管内凝血增加和严重的心理压力有关。 COVID-19 通常表现为神经和神经精神症状，包括头晕、睡眠障碍、认知缺陷、谵妄、幻觉和抑郁。所有这些都表明神经组织受到损害，可能会大大增加神经退行性疾病的发病率并促进痴呆。