Metabolic Syndrome (MetS) increases the risk of cardiovascular disease. Whole red raspberry (WRR) consumption on vascular function was investigated in the obese Zucker rat (OZR), model of MetS. Male OZR and their lean littermates (LZR) were placed on a control (C) or an 8% w/w WRR-enriched diet for8 weeks. Phenylephrine (Phe)-induced vasoconstriction and acetylcholine (Ach)-induced vasorelaxation were measured in aortic rings in the presence or absence of L-N-monomethyl-arginine (L-NMMA) and mefenamic acid (MFA). Phe-induced vasoconstriction was lower in the OZR-C compared to LZR-C (p < 0.05). The WRR diet partially restored aortic response in the OZR-WRR aorta (p < 0.05) compared to OZR- C. The OZR-WRR group pre-treated with L-NMMA increased compared to OZR-C (p < 0.05). Pre-treatment with L-NMMA, maximal relaxation response was higher in the OZR compared to the LZR (p < 0.05). With L-NMMA, maximal relaxation response in OZR-WRR (p < 0.05) was lower compared to the OZR-C. Prostacyclin I2 concentration was higher in the OZR compared to the LZR (p < 0.05) and was attenuated in the OZR-WRR (p < 0.05). Aortic expression of eNOS and COX-2 were downregulated in the OZR-WRR (p < 0.05). In conclusion, WRR restores the impaired vascular tone of the OZR by enhancing Phe-induced vasoconstriction and attenuating Ach-induced vasorelaxation.

中文翻译：

---

食用红树莓（Rubus idaeus）可恢复肥胖zucker大鼠（一种代谢综合征的模型）的主动脉血管收缩和血管松弛的受损。

代谢综合症（MetS）增加了患心血管疾病的风险。在肥胖的祖克大鼠（OZR）（MetS模型）中研究了全红树莓（WRR）对血管功能的消耗。将雄性OZR及其瘦仔猪（LZR）置于对照（C）或8％w / w WRR丰富的饮食中8周。在存在或不存在LN-单甲基精氨酸（L-NMMA）和甲芬那酸（MFA）的情况下，在主动脉环中测量了去氧肾上腺素（Phe）诱导的血管收缩和乙酰胆碱（Ach）诱导的血管松弛。与LZR-C相比，OZR-C中Phe诱导的血管收缩作用较低（p <0.05）。与OZR-C相比，WRR饮食在OZR-WRR主动脉中部分恢复了主动脉反应（p <0.05）。与OZR-C相比，经L-NMMA预处理的OZR-WRR组增加了（p <0.05）。用L-NMMA进​​行预处理，与LZR相比，OZR的最大弛豫响应更高（p <0.05）。使用L-NMMA，与OZR-C相比，OZR-WRR中的最大弛豫响应较低（p <0.05）。与LZR相比，OZR中的前列环素I2浓度更高（p <0.05），OZR-WRR中的前列环素I2浓度降低（p <0.05）。在OZR-WRR中，eNOS和COX-2的主动脉表达下调（p <0.05）。总之，WRR通过增强Phe诱导的血管收缩和减弱Ach引起的血管舒张来恢复OZR受损的血管张力。在OZR-WRR中，eNOS和COX-2的主动脉表达下调（p <0.05）。总之，WRR通过增强Phe诱导的血管收缩和减弱Ach引起的血管舒张来恢复OZR受损的血管张力。在OZR-WRR中，eNOS和COX-2的主动脉表达下调（p <0.05）。总之，WRR通过增强Phe诱导的血管收缩和减弱Ach引起的血管舒张来恢复OZR受损的血管张力。