BACKGROUND:To overcome the unfavorable issues associated with conventional anti-adhesive HA/CMC film, we developed an anti-adhesive thermally cross-linked gelatin film. OBJECTIVE:We tried to clarify the re-attachability of the film and the required properties concerning the film thickness, stiffness and anti-adhesion effect. METHODS:To determine the optimal thickness, 5 kinds of the thickness of gelatin film and the conventional film were analyzed by tensile test, shearing test, buckling test and the tissue injury test. Finally, using the optimal film thickness, we tried to clarify the anti-adhesion effect of the reattached film. RESULTS:The tensile and shearing test showed gelatin films ≥30 μm thick had greater tensile strength and a smaller number of film fractures, than the conventional film. The buckling and tissue injury test showed gelatin films ≥60 μm thick had higher buckling strength and worse injury scores than the conventional film. The anti-adhesive effect of re-attached gelatin film using optimal thickness (30–40 μm) found the anti-adhesion score was significantly better than that of the control. CONCLUSIONS:Provided it has an optimal thickness, gelatin film can be reattached with enough physical strength not to tear, safety stiffness not to induce tissue injury, and a sufficient anti-adhesion effect.

中文翻译：

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抗粘交联明胶膜的再附着性和所需的物理和生物特性的有用性

背景：为了克服传统防粘HA/CMC薄膜存在的不利问题，我们开发了一种防粘热交联明胶薄膜。目的：我们试图阐明薄膜的再附着性和所需的薄膜厚度、刚度和抗粘连效果等性能。方法:通过拉伸试验、剪切试验、屈曲试验和组织损伤试验对5种明胶膜厚度和常规膜厚度进行分析,确定最佳厚度。最后，使用最佳膜厚，我们试图阐明再贴膜的抗粘连效果。结果：拉伸和剪切试验表明，≥30 μm 厚的明胶薄膜比常规薄膜具有更高的拉伸强度和更少的薄膜断裂次数。屈曲和组织损伤试验表明，≥60 μm 厚的明胶薄膜比常规薄膜具有更高的屈曲强度和更差的损伤评分。使用最佳厚度（30-40 μm）重新贴附明胶膜的抗粘连效果发现抗粘连得分明显优于对照。结论:在最佳厚度条件下,明胶膜可以重新贴附,具有足够的物理强度不会撕裂,安全刚度不会引起组织损伤,具有足够的抗粘连作用。