Second near-infrared photothermal materials for combinational nanotheranostics,Chemical Society Reviews

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Second near-infrared photothermal materials for combinational nanotheranostics
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-11-27 , DOI: 10.1039/d0cs00664e
Cheng Xu _{1,

2,

3} , Kanyi Pu _{1,

2,

3,

4,

5}

Affiliation

Second near-infrared photothermal therapy (NIR-II PTT, 1000–1500 nm) has recently emerged as a new phototherapeutic modality with the advantages of deeper penetration, less energy dissipation and minimal normal-tissue toxicity over traditional first NIR PTT (750–1000 nm). However, suboptimal photothermal conversion and limited therapeutic efficacy remain the major challenges for NIR-II PTT. With the convergence in materials science, nanomedicine and biology, multifunctional NIR-II photothermal inorganic or organic materials have been extensively developed to combine NIR-II PTT with other therapeutic modalities for improved efficacies in treating life-threatening diseases including cancer and infection. This review summarizes the recent advances of NIR-II photothermal combinational theranostics pertinent to chemotherapy, immunotherapy, radiotherapy, and photodynamic, sonodynamic, chemodynamic, gene, gas, ionic, vascular and magnetothermal therapy. Potential obstacles and perspectives for future research and clinical translation of this new theranostic modality are also discussed.

中文翻译：

第二种用于组合纳米热学的近红外光热材料

近来第二种近红外光热疗法（NIR-II PTT，1000-1500 nm）作为一种新的光疗方式出现，与传统的第一款NIR PTT（750-1000）相比，具有更深的穿透力，更少的能量耗散和对正常组织的毒性最小的优点。 nm）。然而，对于NIR-II PTT而言，次佳的光热转化和有限的治疗功效仍然是主要挑战。随着材料科学，纳米医学和生物学的融合，已经广泛开发了多功能NIR-II光热无机或有机材料，以将NIR-II PTT与其他治疗方式相结合，以提高治疗威胁生命的疾病（包括癌症和感染）的功效。这篇综述总结了与化学疗法，免疫疗法，放射疗法有关的NIR-II光热组合治疗学的最新进展，以及光动力，声动力，化学动力，基因，气体，离子，血管和磁热疗法。还讨论了这种新的治疗方法的未来研究和临床翻译的潜在障碍和前景。

更新日期：2020-11-27

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