BACKGROUND Moderate and vigorous physical activity is associated with improved outcomes in youth with multiple sclerosis (MS). Physical fitness may also influence disease and health outcomes in this population. OBJECTIVES To determine if there were differences in physical fitness between youth with MS and healthy controls (HC).To examine relationships between physical fitness, physical activity (PA) level, fatigue, depression and disease activity in youth with MS and HC. METHODS Youth with MS (n = 19) and HC (n = 21) completed tests establishing cardiorespiratory-fitness (VO2peak), endurance via 2-minute walk test, and musculoskeletal strength via grip strength (GS). Questionnaires determined fatigue, depression, and PA levels. Weekly PA level was determined by accelerometry. Tests of differences and correlational analyses were used to evaluate physical fitness. RESULTS Youth with MS had lower VO2peak (U = 279, p < 0.0001), endurance (t = 2.6, p = 0.02), and higher body mass index (BMI) (t = -5.9, p = 0.001) than HC. Higher VO2peak was associated with higher moderate to vigorous PAaccelerometer in HC (Spearman-Rho = 0.5, p = 0.03), but not in youth with MS (Spearman-Rho = 0.5, p = 0.06). Lower VO2peak and GS were associated with higher disability (Spearman-Rho = -0.6, p = 0.03) and relapses in MS (Spearman-Rho = -0.52, p = 0.04). CONCLUSIONS Youth with MS have lower levels of fitness, compared with HC. Higher levels of fitness were associated with lower disease activity and disability in youth with MS.

中文翻译：

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患有多发性硬化症的青少年健康水平低

背景 适度和剧烈的身体活动与多发性硬化症 (MS) 青年的预后改善有关。身体素质也可能影响该人群的疾病和健康结果。目的 确定 MS 青年与健康对照组 (HC) 之间的身体素质是否存在差异。检查 MS 和 HC 青年的身体素质、身体活动 (PA) 水平、疲劳、抑郁和疾病活动之间的关系。方法 患有 MS (n = 19) 和 HC (n = 21) 的青少年完成了建立心肺健康 (VO2peak)、2 分钟步行测试耐力和握力 (GS) 肌肉骨骼力量的测试。问卷确定疲劳、抑郁和 PA 水平。每周 PA 水平由加速度计确定。差异测试和相关分析用于评估身体健康。结果 与 HC 相比，患有 MS 的青少年的 VO2peak (U = 279, p < 0.0001)、耐力 (t = 2.6, p = 0.02) 和更高的体重指数 (BMI) (t = -5.9, p = 0.001) 较低。较高的 VO2peak 与 HC 中较高的中度至剧烈 PA 加速度计相关（Spearman-Rho = 0.5，p = 0.03），但与 MS 青年无关（Spearman-Rho = 0.5，p = 0.06）。较低的 VO2peak 和 GS 与较高的残疾（Spearman-Rho = -0.6，p = 0.03）和 MS 复发（Spearman-Rho = -0.52，p = 0.04）相关。结论 与 HC 相比，患有 MS 的青年的健康水平较低。较高水平的健康与 MS 青年的较低疾病活动性和残疾相关。和比 HC 更高的体重指数 (BMI) (t = -5.9, p = 0.001)。较高的 VO2peak 与 HC 中较高的中度至剧烈 PA 加速度计相关（Spearman-Rho = 0.5，p = 0.03），但与 MS 青年无关（Spearman-Rho = 0.5，p = 0.06）。较低的 VO2peak 和 GS 与较高的残疾（Spearman-Rho = -0.6，p = 0.03）和 MS 复发（Spearman-Rho = -0.52，p = 0.04）相关。结论 与 HC 相比，患有 MS 的青年的健康水平较低。较高水平的健康与 MS 青年的较低疾病活动性和残疾相关。和比 HC 更高的体重指数 (BMI) (t = -5.9, p = 0.001)。较高的 VO2peak 与 HC 中较高的中度至剧烈 PA 加速度计相关（Spearman-Rho = 0.5，p = 0.03），但与 MS 青年无关（Spearman-Rho = 0.5，p = 0.06）。较低的 VO2peak 和 GS 与较高的残疾（Spearman-Rho = -0.6，p = 0.03）和 MS 复发（Spearman-Rho = -0.52，p = 0.04）相关。结论 与 HC 相比，患有 MS 的青年的健康水平较低。较高水平的健康与 MS 青年的较低疾病活动性和残疾相关。较低的 VO2peak 和 GS 与较高的残疾（Spearman-Rho = -0.6，p = 0.03）和 MS 复发（Spearman-Rho = -0.52，p = 0.04）相关。结论 与 HC 相比，患有 MS 的青年的健康水平较低。较高水平的健康与 MS 青年的较低疾病活动性和残疾相关。较低的 VO2peak 和 GS 与较高的残疾（Spearman-Rho = -0.6，p = 0.03）和 MS 复发（Spearman-Rho = -0.52，p = 0.04）相关。结论 与 HC 相比，患有 MS 的青年的健康水平较低。较高水平的健康与 MS 青年的较低疾病活动性和残疾相关。