Purpose. Owing to its worldwide spread, the coronavirus disease (COVID-19) epidemic was declared a pandemic by the World Health Organization on March 11, 2020. Angiotensin-converting enzyme 2 (ACE2) is the outer surface protein of the cell membrane that is abundantly distributed in the heart, lungs, and kidneys and plays an important role in molecular docking of the severe acute respiratory syndrome coronavirus 2. In this study, we aimed to analyze the difference in the survival rate according to ACE2 expressions in pan-cancer. Materials and Methods. We downloaded clinical and genomic data from The Cancer Genome Atlas. We used Kaplan-Meier with a log-rank test, and the Cox proportional hazards regression to analyze prognostic significance. Results. In the Kaplan-Meier curve, clear cell renal cell carcinoma (ccRCC), uveal melanoma, and prostate adenocarcinoma showed statistical significance. In the Cox regression, thyroid carcinoma and glioblastoma multiforme and ccRCC showed significant results. Only ccRCC had statistical significance, and high ACE2 expression is related to good prognosis. It is known that the ACE inhibitor, a primary antihypertensive agent, increases ACE2 expression. Conclusion. Based on these results, we believe that the ACE inhibitor will be important to increase the lifespan of ccRCC patients. This study is the first research to offer a recommendation on the use of anti-hypertensive drugs to ccRCC patients.

中文翻译：

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COVID-19 受体 ACE2 的预后意义及肾细胞癌抗高血压药物的推荐


目的。由于冠状病毒病 (COVID-19) 在全球范围内传播，世界卫生组织于 2020 年 3 月 11 日宣布其为大流行病。血管紧张素转换酶 2 (ACE2) 是细胞膜的外表面蛋白，富含分布于心脏、肺和肾脏，在严重急性呼吸综合征冠状病毒2的分子对接中发挥重要作用。在本研究中，我们旨在根据泛癌中ACE2的表达来分析生存率的差异。材料和方法。我们从癌症基因组图谱下载了临床和基因组数据。我们使用 Kaplan-Meier 和对数秩检验以及 Cox 比例风险回归来分析预后意义。结果。在Kaplan-Meier曲线中，透明细胞肾细胞癌（ccRCC）、葡萄膜黑色素瘤和前列腺腺癌显示出统计学显着性。在Cox回归中，甲状腺癌、多形性胶质母细胞瘤和ccRCC显示出显着的结果。仅ccRCC具有统计学意义，且ACE2高表达与良好预后相关。众所周知，ACE 抑制剂是一种主要的抗高血压药物，可增加 ACE2 的表达。结论。基于这些结果，我们相信 ACE 抑制剂对于延长 ccRCC 患者的寿命非常重要。这项研究是第一项为 ccRCC 患者使用抗高血压药物提供建议的研究。