Coagulopathy and syncytial formation are relevant effects of the SARS-CoV-2 infection, but the underlying molecular mechanisms triggering these processes are not fully elucidated. Here, we identified a potential consensus pattern in the Spike S glycoprotein present within the cytoplasmic domain; this consensus pattern was detected in only 79 out of 561,000 proteins (UniProt bank). Interestingly, the pattern was present in both human and bat the coronaviruses S proteins, in many proteins involved in coagulation process, cell–cell interaction, protein aggregation and regulation of cell fate, such as von Willebrand factor, coagulation factor X, fibronectin and Notch, characterized by the presence of the cysteine-rich EGF-like domain. This finding may suggest functional similarities between the matched proteins and the CoV-2 S protein, implying a new possible involvement of the S protein in the molecular mechanism that leads to the coagulopathy and cell fusion in COVID-19 disease.

凝血障碍和合胞体形成是 SARS-CoV-2 感染的相关影响，但触发这些过程的潜在分子机制尚未完全阐明。在这里，我们确定了细胞质结构域中存在的 Spike S 糖蛋白的潜在共有模式；在 561,000 个蛋白质中，仅在 79 个蛋白质中检测到了这种共识模式（UniProt 银行）。有趣的是，这种模式存在于人类和蝙蝠冠状病毒的S蛋白中，以及参与凝血过程、细胞间相互作用、蛋白质聚集和细胞命运调节的许多蛋白质中，例如冯维勒布兰德因子、凝血因子X、纤连蛋白和Notch ，其特征是存在富含半胱氨酸的 EGF 样结构域。这一发现可能表明匹配蛋白与 CoV-2 S 蛋白之间存在功能相似性，这意味着 S 蛋白可能参与导致 COVID-19 疾病中凝血障碍和细胞融合的分子机制。