Abstract

Lactoperoxidase is a glycosylated protein with a molecular mass of 78 kDa, which being excreted in several mammalian secretions. Lactoperoxidase is included in many biological processes and well-known to have biocidal actions, attending as active antibiotics and antiviral agents. This wide-spectrum of biocidal activities mediates via a definite inhibitory system named lactoperoxidase system which acts a potent role in the innate immune response since its activity is not restricted by the antimicrobial effect, but might act a significant role in the hydrolysis of many toxins like aflatoxin. Hence with the current progresses in technology, nanoparticles can offer chances as an active candidate that might be utilized for stabilizing and potentiating the activity of LPO for use in several applications. Due to the variability functions of LPO, this enzyme considers an active target to be encapsulated or coated to NPs for developing novel nanocombinations with controlled surface characteristics. The development of approaches which might enhance conformational stabilization for several weeks of LPO via nanoformulation could improve the biopharmaceutical applicability of this bioactive ingredient. Nanoformulation of LPO enhances novel functions that can be useful in many biotechnological applications like food industry, cosmetic and pharmaceutical applications or to deliver and encapsulate bioactive components.

摘要

乳过氧化物酶是一种糖基化蛋白质，分子量为 78 kDa，可在多种哺乳动物的分泌物中排泄。乳过氧化物酶包含在许多生物过程中，众所周知具有杀生物作用，作为活性抗生素和抗病毒剂。这种广谱的杀生物活性通过称为乳过氧化物酶系统的明确抑制系统介导，该系统在先天免疫反应中发挥有效作用，因为其活性不受抗菌作用的限制，但可能在许多毒素的水解中起重要作用，如黄曲霉毒素。因此，随着当前技术的进步，纳米粒子可以作为一种活性候选物提供机会，可用于稳定和增强 LPO 的活性，以用于多种应用。由于 LPO 的可变函数，该酶考虑将活性靶标封装或涂覆到 NPs 上，以开发具有受控表面特性的新型纳米组合。开发可能通过纳米制剂增强 LPO 构象稳定性数周的方法可以提高这种生物活性成分的生物制药适用性。LPO 的纳米制剂增强了新功能，这些功能可用于许多生物技术应用，如食品工业、化妆品和制药应用，或用于递送和封装生物活性成分。开发可能通过纳米制剂增强 LPO 构象稳定性数周的方法可以提高这种生物活性成分的生物制药适用性。LPO 的纳米制剂增强了新功能，这些功能可用于许多生物技术应用，如食品工业、化妆品和制药应用，或用于递送和封装生物活性成分。开发可能通过纳米制剂增强 LPO 构象稳定性数周的方法可以提高这种生物活性成分的生物制药适用性。LPO 的纳米制剂增强了新功能，这些功能可用于许多生物技术应用，如食品工业、化妆品和制药应用，或用于递送和封装生物活性成分。