Under conditions of high nutrient availability and low ATP synthesis, mitochondria generate reactive oxygen species (ROS) that must be removed to avoid cell injury. Among the enzymes involved in this scavenging process, peroxidases play a crucial role, using NADPH provided mostly by nicotinamide nucleotide transhydrogenase (NNT). However, scarce information is available on how and to what extent ROS formation is linked to mitochondrial oxygen consumption. A new study by Smith et al. shows that NNT activity maintains low ROS levels by means of a fine modulation of mitochondrial oxygen utilization.

中文翻译：

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NNT依赖的ROS去除的能源成本

在高养分利用率和低ATP合成的条件下，线粒体会产生活性氧（ROS），必须将其清除以避免细胞损伤。在这种清除过程中涉及的酶中，过氧化物酶起着至关重要的作用，使用主要由烟酰胺核苷酸转氢酶（NNT）提供的NADPH。但是，关于ROS形成与线粒体耗氧量如何以及在何种程度上相关的信息很少。Smith等人的一项新研究。结果表明，NNT活性通过线粒体氧利用的精细调节而保持了较低的ROS水平。