Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular‐subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological disease involving dementia. Exercise can rescue memory by enhancing hippocampal neurogenesis, but whether exercise affects adult neurogenesis in the ventricular‐subventricular zone remains unresolved. Previously, we reported that exercise induces angiogenesis through activation of the lactate receptor HCA1. The aim of the present study is to investigate HCA₁‐dependent effects on neurogenesis in the two main neurogenic niches.

中文翻译：

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L-乳酸通过乳酸受体HCA1诱导小鼠心室-脑室下区神经发生

成人神经发生发生在大脑的两个主要位置：海马结构的颗粒下区和心室-脑室下区。在衰老和涉及痴呆症的神经系统疾病中，这两个壁龛中的神经发生都会减少。运动可以通过增强海马神经发生来挽救记忆，但运动是否会影响成人脑室-脑室下区的神经发生尚不清楚。以前，我们报道运动通过激活乳酸受体 HCA1 诱导血管生成。本研究的目的是研究 HCA ₁依赖性对两个主要神经源性生态位中神经发生的影响。