We here introduce a Review Series focussing on the important influences circadian rhythms have on immune responses. The three reviews in this series, expertly curated by Rachel Edgar, discuss how the cyclic oscillations in our cellular clock affect the innate and adaptive immune response, and how interactions with the intestinal microbiota, themselves subject to daily oscillations, also influence immune responses. As we understand more about these mechanisms, by which chronobiology contributes to immunology, it is becoming increasingly clear that they have important functions in maintaining health, influence autoimmunity and may contribute to the effectiveness of vaccinations.

中文翻译：

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是时候考虑昼夜节律了


我们在这里介绍一个回顾系列，重点关注昼夜节律对免疫反应的重要影响。本系列中的三篇评论由 Rachel Edgar 精心策划，讨论了我们的细胞时钟中的循环振荡如何影响先天性和适应性免疫反应，以及与肠道微生物群的相互作用（本身受到日常振荡）如何影响免疫反应。随着我们对这些机制的了解越来越多，时间生物学对免疫学的贡献越来越明显，它们在维持健康、影响自身免疫以及可能有助于疫苗接种的有效性方面具有重要功能。