Water Extract of Lemon (WEL) as a Promoter: Green and Regioselective Synthesis of Alkyl‐4‐(1H‐indol‐3 yl)‐2‐alkyl‐4H‐chromene‐3‐carboxylates Using 4H‐chromenes and Indoles,ChemistrySelect

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Water Extract of Lemon (WEL) as a Promoter: Green and Regioselective Synthesis of Alkyl‐4‐(1H‐indol‐3 yl)‐2‐alkyl‐4H‐chromene‐3‐carboxylates Using 4H‐chromenes and Indoles
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-11-27 , DOI: 10.1002/slct.202003542
Vasantha R. ₁ , Dandamudi V Lenin ₁ , L. Chandrashekhara Rao ₂ , Nandigama Satish Kumar ₂

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An efficient, simple, green, regioselective and catalyst‐free synthesis of alkyl‐4‐(1H‐indol‐3yl)‐2‐alkyl‐4H‐chromene‐3‐carboxylates is disclosed by employing indoles and substituted chromene derivatives under mild reaction condition. This is a novel green methodology, simple, eco‐friendly and easy to operate. Biomass‐derived catalyst Water Extract of Lemon (WEL) was used as a promoter for this procedure. The methodology could be applicable for cost‐effective large scale production of alkyl‐4‐(1H‐indol‐3yl)‐2‐alkyl‐4H‐chromene‐3‐carboxylates in good to excellent yield.

中文翻译：

作为促进剂的柠檬水提取物（WEL）：使用4H-色烯和吲哚绿色和区域选择性合成烷基4-（1H-吲哚-3基）-2-烷基-4H-色烯-3-羧酸盐

通过在温和反应下使用吲哚和取代的苯二甲基衍生物，公开了一种高效，简单，绿色，区域选择性和无催化剂的烷基-4-（1 H-吲哚-3-基）-2-烷基-4- H-铬烯-3-羧酸酯的合成方法健康）状况。这是一种新颖的绿色方法，简单，环保且易于操作。生物质催化剂柠檬水提取物（WEL）被用作该程序的促进剂。该方法可适用于具有成本效益的大规模生产烷基-4-（1 H-吲哚-3-基）-2-烷基-4 H-色烯-3-羧酸酯。

更新日期：2020-11-27

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