A series of furo[3,2‐c]pyrones and furo[3,2‐c]coumarins agents were efficiently synthesized and structure recognizable proof was performed by FTIR and NMR. The furo[3,2‐c]pyrones and furo[3,2‐c]coumarins were evaluated against three bacterial strains (Bacillus subtilis, Staphylococcus aureus and Escherichia coli) and two parasitic strains (Aspergillus niger and Candida albicans). The antimicrobial results demonstrated that a couple of compounds showed noteworthy outcomes relating to the standard medications. Compounds 6 b and 9 f indicated great action against Escherichia coli and Bacillus subtilis with MIC value 0.0108 μmol/ml and 0.0120 μmol/ml, respectively. Compound 9 f also showed better activity against fungal strains with MIC value 0.0120 μmol/ml. Based on the outcomes of antimicrobial activities, docking study was performed to know the binding interface of furo[3,2‐c]pyrones and furo[3,2‐c]coumarins with DNA gyrase topoisomerase II.

中文翻译：

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高效的微波辅助合成，呋喃[3,2-c]吡喃酮和呋喃[3,2-c]香豆素的体外抗菌评价以及分子对接研究

高效合成了一系列呋喃[3,2-c]吡喃酮和呋喃[3,2-c]香豆素类药物，并通过FTIR和NMR进行了结构识别证明。分别对三种细菌菌株（枯草芽孢杆菌，金黄色葡萄球菌和大肠杆菌）和两种寄生虫菌株（黑曲霉和白色念珠菌）进行了呋喃[3,2-c]吡喃酮和呋喃[3,2-c]香豆素的评估。抗菌结果表明，几种化合物显示出与标准药物有关的显着结果。化合物6  b和9  ˚F指示针对大动作大肠杆菌和MIC值分别为0.0108μmol/ ml和0.0120μmol/ ml的枯草芽孢杆菌。化合物9  ˚F也表现出抗真菌菌株更好的活性与MIC值0.0120微摩尔/毫升。根据抗菌活性的结果，进行对接研究以了解呋喃[3,2-c]吡喃酮和呋喃[3,2-c]香豆素与DNA促旋酶拓扑异构酶II的结合界面。