Efficient and Sustainable Synthesis of Spiroannulated Hybrid Molecules with Privileged Substructures using Nanostructured Heterogeneous Catalyst,ChemistrySelect

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Efficient and Sustainable Synthesis of Spiroannulated Hybrid Molecules with Privileged Substructures using Nanostructured Heterogeneous Catalyst
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-11-27 , DOI: 10.1002/slct.202003752
Monu Agarwal ₁ , Kanchan Verma ₁ , Yogesh Kumar Tailor ₁ , Sarita Khandelwal ₁ , Esha Rushell ₁ , Sakshi Pathak ₁ , Yogita Kumari ₂ , Kamlendra Awasthi ₂ , Mahendra Kumar ₁

Affiliation

Spiroannulated hybrid molecules with privileged substructures have been synthesized by an efficient and sustainable synthetic protocol involving isocyanide‐based four component reaction of benzene‐1,2‐diamine, 2‐hydroxynaphthalene‐1,4‐dione, cyclic ketones and isocyanides catalyzed by recyclable and reusable nanostructured TiO₂ with Erbium(Er) doping as heterogeneous catalyst. The synthetic protocol with special features, that is, atom and step economy, operational simplicity, synthetic efficiency and superior catalytic activity with sustainability and its recyclability and reusability provided structurally diverse hybrid molecules with unique combination of privileged substructures. The present synthetic protocol will contribute significantly to drug discovery research in view of its synthetic efficiency to synthesize drug‐like molecules with structural complexity. The catalyst was successfully synthesized and characterized by X‐ray diffraction (XRD), Fourier‐transform infrared spectroscopy (FT‐IR), energy‐dispersive X‐ray spectroscopy (EDX), and transmission electron microscopy (TEM).

中文翻译：

高效的纳米结构均相催化剂合成具有特权子结构的螺环杂化分子

已通过有效且可持续的合成规程合成了具有特权子结构的螺环杂化分子，该规程涉及可再循环和可催化的基于异氰化物的苯，1,2-二胺，2-羟基萘-1,4-二酮，环酮和异氰酸酯的四组分反应。可重复使用的纳米结构TiO ₂掺Er（Er）作为多相催化剂。具有特殊功能的合成方案，即原子和步骤经济，操作简单，合成效率和具有可持续性的优异催化活性及其可回收性和可重复使用性，为结构多样的杂化分子提供了特权子结构的独特组合。鉴于其合成具有结构复杂性的类药物分子的合成效率，本合成方案将对药物发现研究做出重大贡献。该催化剂已成功合成并通过X射线衍射（XRD），傅里叶变换红外光谱（FT-IR），能量分散X射线光谱（EDX）和透射电子显微镜（TEM）进行了表征。

更新日期：2020-11-27

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