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Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus
ChemBioChem ( IF 2.6 ) Pub Date : 2020-11-26 , DOI: 10.1002/cbic.202000716 Jessica A I Muller 1, 2 , Nicole Lawrence 1 , Lai Yue Chan 1 , Peta J Harvey 1 , Alysha G Elliott 3 , Mark A T Blaskovich 3 , Jacqueline C Gonçalves 4 , Priscilla Galante 4 , Marcia R Mortari 4 , Mônica C Toffoli-Kadri 2 , Johannes Koehbach 1 , David J Craik 1
ChemBioChem ( IF 2.6 ) Pub Date : 2020-11-26 , DOI: 10.1002/cbic.202000716 Jessica A I Muller 1, 2 , Nicole Lawrence 1 , Lai Yue Chan 1 , Peta J Harvey 1 , Alysha G Elliott 3 , Mark A T Blaskovich 3 , Jacqueline C Gonçalves 4 , Priscilla Galante 4 , Marcia R Mortari 4 , Mônica C Toffoli-Kadri 2 , Johannes Koehbach 1 , David J Craik 1
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Where is thy sting? Wasp venom‐derived α‐helical peptides and analogues were tested for antimicrobial and cytotoxic activity. The analogues were less toxic to cells and could accumulate inside cancer cells. Protonectin‐F kills cancer cells and bacteria whereas neuroVAL is a nontoxic cell‐penetrating peptide.
中文翻译：
来自黄蜂 Parachartergus fraternus 的合成肽的抗菌和抗癌特性
你的刺在哪里？测试了黄蜂毒液衍生的 α-螺旋肽和类似物的抗菌和细胞毒活性。这些类似物对细胞的毒性较小，可以在癌细胞内积聚。Protonectin-F 可以杀死癌细胞和细菌，而 NeuroVAL 是一种无毒的细胞穿透肽。
更新日期：2020-11-26
中文翻译：
来自黄蜂 Parachartergus fraternus 的合成肽的抗菌和抗癌特性
你的刺在哪里？测试了黄蜂毒液衍生的 α-螺旋肽和类似物的抗菌和细胞毒活性。这些类似物对细胞的毒性较小，可以在癌细胞内积聚。Protonectin-F 可以杀死癌细胞和细菌，而 NeuroVAL 是一种无毒的细胞穿透肽。
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