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Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer
BioEssays ( IF 3.2 ) Pub Date : 2020-11-27 , DOI: 10.1002/bies.202000180 Vladimir N Nikolenko 1, 2 , Marine V Oganesyan 1 , Maria V Sankova 1 , Kirill V Bulygin 1, 2 , Andzhela D Vovkogon 1 , Negoriya A Rizaeva 1 , Mikhail Y Sinelnikov 3
BioEssays ( IF 3.2 ) Pub Date : 2020-11-27 , DOI: 10.1002/bies.202000180 Vladimir N Nikolenko 1, 2 , Marine V Oganesyan 1 , Maria V Sankova 1 , Kirill V Bulygin 1, 2 , Andzhela D Vovkogon 1 , Negoriya A Rizaeva 1 , Mikhail Y Sinelnikov 3
Affiliation
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The human intestines are constantly under the influence of numerous pathological factors: enteropathogenic microorganisms, food antigens, physico‐chemical stress associated with digestion and bacterial metabolism, therefore it must be provided with a system of protection against adverse impact. Recent studies have shown that Paneth cells play a crucial role in maintaining homeostasis of the small intestines. Paneth cells perform many vital functions aimed at maintaining a homeostatic balance between normal microbiota, infectious pathogens and the human body, regulate the qualitative composition and number of intestinal microorganisms, prevent the introduction of potentially pathogenic species, and protect stem cells from damage. Paneth cells take part in adaptive and protective‐inflammatory reactions. Paneth cells maintain dynamic balance between microbial populations, and the macroorganism, preventing the development of intestinal infections and cancer. They play a crucial role in gastrointestinal homeostasis and may be key factors in the etiopathological progression of intestinal diseases.
中文翻译：
潘氏细胞：维持动态微生物组-宿主稳态，预防炎症和癌症
人体肠道不断受到多种病理因素的影响：肠道病原微生物、食物抗原、与消化和细菌代谢相关的理化应激，因此必须为其提供防止不利影响的系统。最近的研究表明，潘氏细胞在维持小肠的稳态方面起着至关重要的作用。潘氏细胞执行许多重要功能，旨在维持正常微生物群、传染性病原体和人体之间的稳态平衡，调节肠道微生物的定性组成和数量，防止潜在致病物种的引入，并保护干细胞免受损害。潘氏细胞参与适应性和保护性炎症反应。潘氏细胞维持微生物种群和宏观生物之间的动态平衡，防止肠道感染和癌症的发展。它们在胃肠道稳态中起着至关重要的作用，并且可能是肠道疾病病理学进展的关键因素。
更新日期：2020-11-27
中文翻译：
潘氏细胞：维持动态微生物组-宿主稳态，预防炎症和癌症
人体肠道不断受到多种病理因素的影响：肠道病原微生物、食物抗原、与消化和细菌代谢相关的理化应激，因此必须为其提供防止不利影响的系统。最近的研究表明，潘氏细胞在维持小肠的稳态方面起着至关重要的作用。潘氏细胞执行许多重要功能，旨在维持正常微生物群、传染性病原体和人体之间的稳态平衡，调节肠道微生物的定性组成和数量，防止潜在致病物种的引入，并保护干细胞免受损害。潘氏细胞参与适应性和保护性炎症反应。潘氏细胞维持微生物种群和宏观生物之间的动态平衡，防止肠道感染和癌症的发展。它们在胃肠道稳态中起着至关重要的作用，并且可能是肠道疾病病理学进展的关键因素。
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