Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration,Advanced Science

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Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration
Advanced Science ( IF 14.3 ) Pub Date : 2020-11-27 , DOI: 10.1002/advs.202002589
Zimu Li ₁ , Xiaoting Shan ₁ , Zhidong Chen ₁ , Nansha Gao ₁ , Wenfeng Zeng ₁ , Xiaowei Zeng ₁ , Lin Mei _{1,

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Affiliation

The impermeable barrier of solid tumors due to the complexity of their components limits the treatment effect of nanomedicine and hinders its clinical translation. Several methods are available to increase the penetrability of nanomedicine, yet they are too complex to be effective, operational, or practical. Surface modification employs the characteristics of direct contact between multiphase surfaces to achieve the most direct and efficient penetration of solid tumors. Furthermore, their simple operation makes their use feasible. In this review, the latest surface modification strategies for the penetration of nanomedicine into solid tumors are summarized and classified into “bulldozer strategies” and “mouse strategies.” Additionally, the evaluation methods, existing problems, and the development prospects of these technologies are discussed.

中文翻译：

表面修饰技术在肿瘤深部穿透纳米医学中的应用

实体瘤由于其成分的复杂性而具有不可渗透的屏障，限制了纳米医学的治疗效果并阻碍了其临床转化。有几种方法可以提高纳米医学的渗透性，但它们过于复杂，无法有效、可操作或实用。表面修饰利用多相表面直接接触的特点，实现对实体瘤最直接、最高效的穿透。此外，其简单的操作使得它们的使用变得可行。本综述总结了纳米医学渗透实体瘤的最新表面修饰策略，并将其分为“推土机策略”和“小鼠策略”。此外，还讨论了这些技术的评价方法、存在的问题以及发展前景。

更新日期：2021-01-07

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