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On water synthesis of the novel 2-oxo-1,2,3,4-tetrahydropyrimidines
Tetrahedron ( IF 2.1 ) Pub Date : 2020-11-27 , DOI: 10.1016/j.tet.2020.131790 Emilija Milović , Nenad Janković , Goran A. Bogdanović , Jelena Petronijević , Nenad Joksimović
中文翻译:
关于新型2-氧-1,2,3,4-四氢嘧啶的水合成
更新日期:2020-12-17
Tetrahedron ( IF 2.1 ) Pub Date : 2020-11-27 , DOI: 10.1016/j.tet.2020.131790 Emilija Milović , Nenad Janković , Goran A. Bogdanović , Jelena Petronijević , Nenad Joksimović
A simple on water approach for the synthesis of novel tetrahydropyrimidine (THPM) derivatives has been developed under a green and sustainable fashion. For the first time, a deuterated Biginelli’s hybrid was synthesized. Novel THPMs are suitable for further derivatization and could be an excellent toolkit for lead-oriented synthesis and/or cross-coupling reactions.
中文翻译:
关于新型2-氧-1,2,3,4-四氢嘧啶的水合成
已经以绿色和可持续的方式开发了一种简单的水合成新的四氢嘧啶(THPM)衍生物的方法。首次合成了氘化的Biginelli杂种。新型THPM适用于进一步衍生化,并且可能是面向铅的合成和/或交叉偶联反应的出色工具包。