Abstract In this paper the exploration of specific imprinted sorbent for 4-hydroxy-3-nitrophenylacetic acid (NHPA), an indicator of 3-nitrotyrosine, a biomarker of pathophysiological states, was described. The optimization of synthetic protocol, supported by theoretical studies, allowed to select NHPA imprinted poly(acrylic acid-co-ethylene glycol dimethacrylate) as the most specific polymer with imprinting factor equal to 2.27. The acrylic copolymers were characterized, revealing differences between the imprinted and non-imprinted material in the adsorption binding capacities (0.54 ± 0.12 and 0.335 ± 0.073 μmol g-1, respectively), heterogeneity indices (0.47 and 0.72), pseudo-second order kinetics constants (0.251 and 0.077 g μmol -1 min-1, respectively), and total specific surface areas (51.8 and 292.3 m2 g-1, respectively). The significant difference in the microstructure of pores was considered as the crucial factor responsible for sorption properties of analyzed materials.

中文翻译：

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深入了解 4-羟基-3-硝基苯乙酸印迹的聚（丙烯酸-共聚乙二醇二甲基丙烯酸酯）吸附剂的形态、孔结构和吸附性能

摘要 本文描述了 4-羟基-3-硝基苯乙酸 (NHPA) 的特异性印迹吸附剂的探索，NHPA 是病理生理状态的生物标志物 3-硝基酪氨酸的指示剂。在理论研究的支持下, 合成协议的优化允许选择 NHPA 印迹聚 (丙烯酸-co-乙二醇二甲基丙烯酸酯) 作为最具体的聚合物, 印迹因子等于 2.27。对丙烯酸共聚物进行了表征，揭示了印迹和非印迹材料在吸附结合能力（分别为 0.54 ± 0.12 和 0.335 ± 0.073 μmol g-1）、异质性指数（0.47 和 0.72）、伪二级动力学方面的差异常数（分别为 0.251 和 0.077 g μmol -1 min-1）和总比表面积（分别为 51.8 和 292.3 m2 g-1）。