Infectious human diseases acquired from bivalve shellfish consumption constitute a public health threat. These health threats are largely related to the filter-feeding phenomenon, by which bivalve organisms retain and concentrate pathogenic bacteria from their surrounding waters. Even after depuration, bivalve shellfish are still involved in outbreaks caused by pathogenic bacteria, which increases the demand for new and efficient strategies to control transmission of shellfish infection. Bacteriophage (or phage) therapy represents a promising, tailor-made approach to control human pathogens in bivalves, but its success depends on a deep understanding of several factors that include the bacterial communities present in the harvesting waters, the appropriate selection of phage particles, the multiplicity of infection that produces the best bacterial inactivation, chemical and physical factors, the emergence of phage-resistant bacterial mutants and the life cycle of bivalves. This review discusses the need to advance phage therapy research for bivalve decontamination, highlighting their efficiency as an antimicrobial strategy and identifying critical aspects to successfully apply this therapy to control human pathogens associated with bivalve consumption.

从食用双壳贝类中获取的人类传染病构成了公共卫生威胁。这些健康威胁在很大程度上与过滤器进食现象有关，双壳类生物通过这种进食现象保留并浓缩了周围水域中的病原细菌。即使在净化后，双壳贝类仍然参与由病原菌引起的暴发，这增加了对控制贝类感染传播的新型有效策略的需求。噬菌体（或噬菌体）治疗是双壳类一个有前途的，量身定制的方法来控制人类病原体，但它的成功取决于几个因素，其中包括目前在收获海域的细菌群落，噬菌体颗粒的适当选择有深刻的理解，导致最佳细菌灭活，化学和物理因素，抗噬菌体细菌突变体的出现以及双壳类动物的生命周期的多种感染。这篇综述讨论了需要进行噬菌体治疗以进行双壳类去污的研究，强调其作为抗菌策略的效率，并确定关键方面，以成功地将该治疗用于控制与双壳类食用有关的人类病原体。