The intrinsic dynamic nature of chromosomes is emerging as a fundamental component in regulating DNA transcription, replication, and damage-repair among other nuclear functions. With this increased awareness, reinforced over the last ten years, many new experimental techniques, mainly based on microscopy and chromosome conformation capture, have been introduced to study the genome in space and time. Owing to the increasing complexity of these cutting-edge techniques, computational approaches have become of paramount importance to interpret, contextualize, and complement such experiments with new insights. Hence, it is becoming crucial for experimental biologists to have a clear understanding of the diverse theoretical modeling approaches available and the biological information each of them can provide.

染色体的内在动态特性正在成为调节 DNA 转录、复制和损伤修复等核功能的基本组成部分。随着这种认识的提高，在过去十年中得到加强，许多新的实验技术，主要基于显微镜和染色体构象捕获，已经被引入来研究空间和时间的基因组。由于这些尖端技术的复杂性越来越高，计算方法对于用新的见解解释、背景化和补充这些实验变得至关重要。因此，对于实验生物学家来说，清楚地了解可用的各种理论建模方法以及每种方法可以提供的生物学信息变得至关重要。