Abstract The clinical utilities of many drugs were limited by poor solubility significantly for a long time until the distinguished development of nano drug carrier for enhancing their bioavailability. However, most of nano drug carriers were involved in extremely complex synthesis procedures, unstable quality control, and also the indeterminate pharmacokinetics in drug release phase. In this study, we designed and synthesized a novel nano drug carrier aiming to ameliorate the solubility of curcumin. Hydrophobins, as amphiphilic proteins from filamentous fungi, attracted numerous attentions in biomaterials since their distinguished natural surfactant activities. Herein, as a novel nano drug carrier, hydrophobins were formed into nanoparticles containing curcumin in spontaneous manner by the strong surfactant activity of hydrophobins. In biomedical assays, the nanoparticles showed remarkable cell uptake efficiency, cell proliferation inhibitory and antitumor activity in intro and in vivo. In brief, it was ascertained that hydrophobins are capable to be employed as an efficient drug carrier for improving the poor solubility, low bioavailability of drugs such as curcumin. It was convinced that the easy-operation and safety properties of hydrophobins might prompt the applications of hydrophobins in pharmaceutics for many other drugs in future.

中文翻译：

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疏水蛋白 HGFI 可改善姜黄素的纳米颗粒形成、稳定性和溶解性

摘要 长期以来，许多药物的临床效用受到溶解度差的显着限制，直到纳米药物载体的显着发展以提高其生物利用度。然而，大多数纳米药物载体都涉及极其复杂的合成程序、不稳定的质量控制以及药物释放阶段的不确定药代动力学。在这项研究中，我们设计并合成了一种旨在改善姜黄素溶解度的新型纳米药物载体。疏水蛋白作为来自丝状真菌的两亲性蛋白质，由于其卓越的天然表面活性活性而在生物材料中引起了广泛关注。在此，作为一种新型纳米药物载体，疏水蛋白通过疏水蛋白的强表面活性活性自发形成含有姜黄素的纳米颗粒。在生物医学分析中，纳米颗粒在体内外均显示出显着的细胞摄取效率、细胞增殖抑制和抗肿瘤活性。简而言之，已经确定疏水蛋白能够用作有效的药物载体，以改善姜黄素等药物的溶解性差、生物利用度低的问题。相信疏水蛋白的易于操作和安全的特性可能会促进疏水蛋白在未来许多其他药物的制药中的应用。