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The yin and yang of mitochondrial Ca2+ signaling in cell physiology and pathology
Cell Calcium ( IF 4.3 ) Pub Date : 2020-11-26 , DOI: 10.1016/j.ceca.2020.102321
Riccardo Filadi 1 , Elisa Greotti 1
Affiliation  

Mitochondria are autonomous and dynamic cellular organelles orchestrating a diverse range of cellular activities. Numerous cell-signaling pathways target these organelles and Ca2+ is one of the most significant. Mitochondria are able to rapidly and transiently take up Ca2+, thanks to the mitochondrial Ca2+ uniporter complex, as well as to extrude it through the Na+/Ca2+ and H+/Ca2+ exchangers. The transient accumulation of Ca2+ in the mitochondrial matrix impacts on mitochondrial functions and cell pathophysiology. Here we summarize the role of mitochondrial Ca2+ signaling in both physiological (yang) and pathological (yin) processes and the methods that can be used to investigate mitochondrial Ca2+ homeostasis. As an example of the pivotal role of mitochondria in pathology, we described the state of the art of mitochondrial Ca2+ alterations in different pathological conditions, with a special focus on Alzheimer’s disease.



中文翻译:

细胞生理学和病理学中线粒体 Ca2+ 信号传导的阴阳

线粒体是自主和动态的细胞器,协调各种细胞活动。许多细胞信号通路以这些细胞器为目标,Ca 2+是最重要的途径之一。由于线粒体 Ca 2+单向转运体复合物,线粒体能够快速和瞬时吸收 Ca 2+,并通过 Na + /Ca 2+和 H + /Ca 2+交换器将其挤出。Ca 2+在线粒体基质中的瞬时积累影响线粒体功能和细胞病理生理学。这里我们总结一下线粒体Ca 2+的作用生理(阳)和病理(阴)过程中的信号传导以及可用于研究线粒体 Ca 2+稳态的方法。作为线粒体在病理学中的关键作用的一个例子,我们描述了不同病理条件下线粒体 Ca 2+改变的最新技术,特别关注阿尔茨海默病。

更新日期:2020-12-09
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