当前位置: X-MOL 学术Biochem. Syst. Ecol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae)
Biochemical Systematics and Ecology ( IF 1.6 ) Pub Date : 2020-11-27 , DOI: 10.1016/j.bse.2020.104201
Kevine Johane Dongmo Jumeta , Donald Ulrich Kenou Kagho , Joel Eddy Terence Ateba , Yannick Stéphane Fongang Fotsing , Jean Jules Kezetas Bankeu , Norbert Sewald , Bruno Lenta Ndjakou , Lateef Mehreen , Muhammad Shaiq Ali , Augustin Silvère Ngouela

A phytochemical investigation of the roots of Celtis adolphi-friderici Engl. led to the isolation of a previously undescribed cerebroside named, eloundemnoside (1), alongside with seventeen known compounds (2–18). Their chemical structures were elucidated based on the analysis of their NMR and MS data. All the compounds were isolated from this specie for the first time, while eight known compounds (4–5, 12–13, 15–18) are obtained from the genus Celtis for the first time. The isolates were screened for their antioxidant, lipoxygenase, urease, and butyrylcholinesterase enzyme inhibitory activities. Compounds 4, 7 and 12 showed good antioxidant activities with IC50 values of 22.2, 29.3, and 13.2 μM, respectively. In addition, azelaic acid (12) showed the best lipoxygenase inhibition (IC50 value of 16.3 μM), while friedelin (2) exhibited the highest inhibition of urease with an IC50 value of 15.3 μM. However, all the compounds tested had moderate butyrylcholinesterase inhibitory properties. The chemophenetic relationship of the isolates and their significance were discussed.



中文翻译:

Celtis adolphi-friderici Engl的一种新的脑苷和生物活性化合物。(大麻科)

Celtis adolphi-friderici Engl根的植物化学研究。导致分离出一种先前未描述的脑苷,一种名为Eloundemnoside(1),以及17种已知化合物(2-18)。根据对NMR和MS数据的分析,阐明了它们的化学结构。首次从该物种中分离出所有化合物,而首次从Celtis属中获得了8种已知化合物(4–5、12–13、15–18)。筛选分离物的抗氧化剂,脂氧合酶,脲酶和丁酰胆碱酯酶抑制活性。化合物4712与IC显示出良好的抗氧化活性50倍22.2,29.3,和13.2的值 μ男,分别。此外,壬二酸(12)显示出最好的脂氧合酶抑制(IC 50 16.3值 μ M),而木栓(2)显示出尿素酶的最高抑制,其IC 50 15.3值 μ M.然而,所有的测试化合物具有中等的丁酰胆碱酯酶抑制特性。讨论了分离株之间的趋化关系及其意义。

更新日期:2020-11-27
down
wechat
bug