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Burn injury induces elevated inflammatory traffic: the role of NF-κB
Inflammation Research ( IF 4.8 ) Pub Date : 2020-11-27 , DOI: 10.1007/s00011-020-01426-x
Benu George 1 , T V Suchithra 1 , Nitish Bhatia 2
Affiliation  

A burn insult generally sustains a hypovolemic shock due to a significant loss of plasma from the vessels. The burn injury triggers the release of various mediators, such as reactive oxygen species (ROS), cytokines, and inflammatory mediators. Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), stemming from foreign microbial discharge and damaged tissue or necrotic cells from the burn-injured site, enter the systemic circulation, activate toll-like receptors (TLRs), and trigger the excessive secretion of cytokines and inflammatory mediators. Inflammation plays a vital role in remodeling an injured tissue, detoxifying toxins, and helps in the healing process. A transcription factor, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), contributes to a variety of physiological and pathological conditions, including immune response, cell death, cell survival, and inflammatory processes. During the pathogenesis of a burn wound, upregulation of various cytokines and growth factors lead to undesirable tissue inflammation. Thus, NF-κB, a dominant moderator of inflammation, needs to be altered to prove beneficial to the treatment of burns or other inflammation-associated diseases. This review addresses the relationship between NF-κB and elevated inflammation in a burn condition that could potentially be altered to induce an early wound-healing mechanism of burn wounds.



中文翻译:

烧伤导致炎症流量升高:NF-κB 的作用

由于血浆从血管中大量流失,烧伤通常会持续低血容量性休克。烧伤会触发各种介质的释放,如活性氧 (ROS)、细胞因子和炎症介质。损伤相关分子模式 (DAMP) 和病原体相关分子模式 (PAMP),源自外来微生物排放和烧伤部位受损组织或坏死细胞,进入体循环,激活 Toll 样受体 (TLR),并引发细胞因子和炎症介质的过度分泌。炎症在重塑受伤组织、排毒和帮助愈合过程中起着至关重要的作用。活化 B 细胞 (NF-κB) 的转录因子、核因子 kappa-轻链增强子,导致多种生理和病理状况,包括免疫反应、细胞死亡、细胞存活和炎症过程。在烧伤创面的发病过程中,各种细胞因子和生长因子的上调会导致不良的组织炎症。因此,需要改变炎症的主要调节剂 NF-κB 以证明对治疗烧伤或其他炎症相关疾病有益。这篇综述讨论了 NF-κB 与烧伤条件下炎症升高之间的关系,这种关系可能被改变以诱导烧伤伤口的早期伤口愈合机制。各种细胞因子和生长因子的上调导致不希望的组织炎症。因此,需要改变炎症的主要调节剂 NF-κB 以证明对治疗烧伤或其他炎症相关疾病有益。这篇综述讨论了 NF-κB 与烧伤条件下炎症升高之间的关系,这种关系可能被改变以诱导烧伤伤口的早期伤口愈合机制。各种细胞因子和生长因子的上调导致不希望的组织炎症。因此,需要改变炎症的主要调节剂 NF-κB 以证明对治疗烧伤或其他炎症相关疾病有益。这篇综述讨论了 NF-κB 与烧伤条件下炎症升高之间的关系,这种关系可能被改变以诱导烧伤伤口的早期伤口愈合机制。

更新日期:2020-11-27
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