Purpose of Review

This review focuses on the complex interactions between hyperglycemia and bone fragility and the effects of antidiabetic medications on bone metabolism.

Recent Findings

Type 2 diabetes (T2D) is associated with increased risk of bone fracture even in those with increased or normal bone mineral density (BMD). The pathophysiology of diabetic bone disease is not completely understood, but it is thought to be multifactorial and associated with complex cross talk among factors such as AGEs, IGF-1, enteric hormones, and pro-inflammatory cytokines. Treatment for T2D may have an impact on bone metabolism.

Summary

Diabetic bone disease should be considered a serious complication of long-standing T2D.

中文翻译：

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2型糖尿病和抗糖尿病药物对骨代谢的影响

审查目的

这篇综述着重于高血糖与骨骼脆弱性之间的复杂相互作用以及抗糖尿病药物对骨骼代谢的影响。

最近的发现

2型糖尿病（T2D）与骨折风险增加相关，即使在那些具有增加或正常的骨矿物质密度（BMD）的患者中也是如此。糖尿病性骨病的病理生理学尚未完全了解，但被认为是多因素的，并且与AGEs，IGF-1，肠激素和促炎细胞因子等因素之间的复杂串扰相关。T2D的治疗可能会影响骨骼代谢。

概要

糖尿病性骨病应视为长期T2D的严重并发症。