An all-in-one theranostic nanoplatform based on upconversion dendritic mesoporous silica nanocomposites for synergistic chemodynamic/photodynamic/gas therapy,Nanoscale

当前位置： X-MOL 学术 › Nanoscale › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

An all-in-one theranostic nanoplatform based on upconversion dendritic mesoporous silica nanocomposites for synergistic chemodynamic/photodynamic/gas therapy
Nanoscale ( IF 5.8 ) Pub Date : 2020-11-13 , DOI: 10.1039/d0nr06790c
Shikai Liu _{1,

2,

3,

4,

5} , Wenting Li _{1,

2,

3,

4,

5} , Shuming Dong _{1,

2,

3,

4,

5} , Fangmei Zhang _{1,

2,

3,

4,

5} , Yushan Dong _{1,

2,

3,

4,

5} , Boshi Tian _{1,

2,

3,

4,

5} , Fei He _{1,

2,

3,

4,

5} , Shili Gai _{1,

2,

3,

4,

5} , Piaoping Yang _{1,

2,

3,

4,

5}

Affiliation

Gasotransmitters with high therapeutic efficacy and biosafety have been drawing the attention of researchers. Nevertheless, how to effectively deliver gases to and precisely control their generation at the lesion as well as integrate them with other therapies to realize precision therapy have remained elusive. Herein, we report a versatile Cu²⁺-initiated nitric oxide (NO) nanocomposite for multimodal imaging-guided synergistic chemodynamic/photodynamic/gas therapy. After the nanomedicine was ingested by tumor cells, the acidic tumor microenvironment accelerated the decomposition of CuO₂ and simultaneously triggered the Fenton-like catalytic reaction of Cu²⁺ and H₂O₂ to produce highly toxic ˙OH. By virtue of the NO generation and glutathione depletion, UMNOCC-PEG can relieve the antioxidant capacity and hypoxia of the tumor to improve the efficiency of chemodynamic therapy (CDT) and photodynamic therapy (PDT). Importantly, NO and reactive oxygen species (ROS) can generate reactive nitrogen species (RNS), which can result in DNA damage, further improving the therapeutic effect (cell apoptosis rate up to 93.4%). Moreover, the inherent properties of lanthanide ions endow UMNOCC-PEG with upconversion luminescence (UCL), CT and MRI trimodal imaging capability, achieving precise cancer treatment. By taking advantage of these features, the strategy developed here may provide a promising application foreground to conquer malignant tumors.

中文翻译：

一种基于上转换树突状介孔二氧化硅纳米复合材料的多用途治疗药物纳米平台，用于协同化学动力学/光动力学/气体治疗

具有高治疗功效和生物安全性的气体递质已引起研究人员的注意。然而，如何有效地将气体输送到病灶并精确控制其在病灶处的生成以及如何将其与其他疗法结合以实现精确疗法仍然难以捉摸。在这里，我们报告了一种多用途的Cu ²⁺引发的一氧化氮（NO）纳米复合材料，用于多峰成像引导的协同化学动力学/光动力学/气体治疗。肿瘤细胞摄取纳米药物后，酸性肿瘤微环境加速了CuO ₂的分解，同时引发了Cu ²⁺和H ₂ O ₂的Fenton样催化反应。产生剧毒的˙OH 借助NO生成和谷胱甘肽耗竭，UMNOCC-PEG可以减轻肿瘤的抗氧化能力和缺氧，从而提高化学动力疗法（CDT）和光动力疗法（PDT）的效率。重要的是，NO和活性氧（ROS）可以生成活性氮（RNS），这可能导致DNA损伤，从而进一步提高治疗效果（细胞凋亡率高达93.4％）。此外，镧系元素离子的固有特性使UMNOCC-PEG具有上转换发光（UCL），CT和MRI三峰成像功能，从而实现了精确的癌症治疗。通过利用这些特征，本文开发的策略可以为征服恶性肿瘤提供有希望的应用前景。

更新日期：2020-11-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11