Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers,RSC Medicinal Chemistry

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Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-11-19 , DOI: 10.1039/d0md00284d
Zoë Rachael Goddard _{1,

2,

3,

4} , Andrew Michael Beekman _{1,

2,

3,

4} , Marco M. D. Cominetti _{1,

2,

3,

4} , Maria A. O'Connell _{1,

2,

3,

4} , Isabelle Chambrier _{2,

3,

4,

5} , Michael J. Cook _{2,

3,

4,

5} , María J. Marín _{2,

3,

4,

5} , David A. Russell _{2,

3,

4,

5} , Mark Searcey _{1,

2,

3,

4}

Affiliation

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

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