In recent times, a powerful tool of combinatorial synthesis has been used for the preparation of large chemical entities through a small set up of reactions between different building blocks using solid-phase and solution-phase techniques. This method reduced the time and cost of the drug discovery process substantially. Thousands of compounds are synthesised in a few reactions through combinatorial synthesis instead of getting a few compounds in the traditional method. This method also helps to identify chemical lead of the compounds and optimise them through the biological screening using a high-throughput method. There is no review concerning the recent research finding of combinatorial synthesis. Hence, an attempt had been made on the latest research findings (2002–2020) of newly synthesised compounds using combinatorial synthesis and their biological activities. To the best of our knowledge, the current review has completely analysed the importance of combinatorial synthesis and furnished an overview of solid-phase and solution-phase techniques as well as helped mankind by improving higher productivity at low cost, lead identification and optimization and preventing environmental pollution.

中文翻译：

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现代合成方法的最新进展概述——组合合成

最近，一种强大的组合合成工具已被用于通过使用固相和溶液相技术在不同构件之间进行小型反应来制备大型化学实体。这种方法大大减少了药物发现过程的时间和成本。数以千计的化合物通过组合合成在几个反应中合成，而不是传统方法中得到几个化合物。该方法还有助于识别化合物的化学铅，并通过使用高通量方法的生物筛选对其进行优化。组合合成的最新研究成果未见综述。因此，对使用组合合成及其生物活性的新合成化合物的最新研究成果（2002-2020）进行了尝试。据我们所知，本综述全面分析了组合合成的重要性，概述了固相和液相技术，并通过以低成本提高生产力、铅识别和优化以及预防环境污染。