The snoRNA host gene SNHG15 produces a long non-coding RNA (lncRNA) with a short half-life and has been reported to be dysregulated in multiple cancers and has recently been found to be correlated with tumour progression. Therefore, this meta-analysis was performed to evaluate the generalised prognostic role of small nucleolar RNA host gene 15 (SNHG15) in malignancies, based on variable data from different studies. Four public databases were used to identify eligible studies. The association between prognostic indicators and clinical features was extracted and pooled to estimate the hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs). Publication bias was measured using Begg’s test and Egger’s test, and the stability of pooled results were measured using sensitivity analysis. Additionally, an online database based on The Cancer Genome Atlas (TCGA) was screened to further validate our results. Ultimately, we predicted the molecular regulation of SNHG15 based on the public databases. In total, 11 studies including 1087 patients were ultimately enrolled in our meta-analysis. We found that SNHG15 overexpression was associated with worse overall survival (OS) and disease-free survival (DFS), and this was validated in the Gene Expression Profiling Interactive Analysis (GEPIA) cohort. Moreover, increased SNHG15 expression suggested advanced TNM stage and LNM, but was not associated with age, gender, or tumour size. No publication bias or instability of the results was observed. SNHG15 was significantly upregulated in seven cancers and elevated expression of SNHG15 indicated shorter OS and DFS in five malignancies based on the validation using the GEPIA cohort. Further functional prediction indicated that SNHG15 may participate in some cancer-related pathways. Upregulation of lncRNA SNHG15 was notably associated with worse prognosis and clinical features, suggesting that SNHG15 might serve as a novel prognostic factor in various cancers.

中文翻译：

---

各种癌症中的长非编码RNA SNHG15：元和生物信息学分析

snoRNA宿主基因SNHG15产生长的非编码RNA（lncRNA），半衰期短，据报道在多种癌症中表达异常，最近发现与肿瘤进展相关。因此，根据来自不同研究的可变数据，进行了这项荟萃分析，以评估小核仁RNA宿主基因15（SNHG15）在恶性肿瘤中的普遍预后作用。使用四个公共数据库来识别合格的研究。提取和合并预后指标和临床特征之间的关联，以估计具有95％置信区间（CI）的危险比（HR）或优势比（OR）。使用Begg检验和Egger检验测量出版偏倚，并使用敏感性分析测量汇总结果的稳定性。另外，对基于癌症基因组图谱（TCGA）的在线数据库进行了筛选，以进一步验证我们的结果。最终，我们基于公共数据库预测了SNHG15的分子调控。总共有11项研究（包括1087例患者）最终纳入了我们的荟萃分析。我们发现SNHG15过表达与较差的总生存期（OS）和无病生存期（DFS）相关，这在基因表达谱交互分析（GEPIA）队列中得到了验证。此外，增加的SNHG15表达提示TNM分期和LNM晚期，但与年龄，性别或肿瘤大小无关。没有观察到发表偏见或结果不稳定。基于使用GEPIA队列的验证，SNHG15在7种癌症中显着上调，SNHG15的表达升高表明5个恶性肿瘤的OS和DFS较短。进一步的功能预测表明SNHG15可能参与了一些与癌症相关的途径。lncRNA SNHG15的上调与不良预后和临床特征显着相关，这表明SNHG15可能是各种癌症中的一种新的预后因子。