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Zwitterionic hydrogel for sustained release of growth factors to enhance wound healing
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-16 , DOI: 10.1039/d0bm01608j Zecong Xiao 1 , Xinyao Zheng 2 , Ying An 3 , Kangning Wang 3 , Junwen Zhang 4 , Huacheng He 4 , Jiang Wu 3
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-16 , DOI: 10.1039/d0bm01608j Zecong Xiao 1 , Xinyao Zheng 2 , Ying An 3 , Kangning Wang 3 , Junwen Zhang 4 , Huacheng He 4 , Jiang Wu 3
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Growth factors (GFs) have been well known for their therapeutic effects on wound healing. Due to their vulnerable biostability, biomaterial carriers are usually used to deliver GFs to maintain their bioactivity. Among the carriers, PEG hydrogels are the most widely applied. But the uncontrolled release of GFs and their immunogenicity dramatically retard the application of PEG hydrogels as carriers of GFs. Herein, FGF2 loaded zwitterionic sulfobetaine methacrylate (SBMA) hydrogels were developed, and it was revealed that these hydrogels were more effective in delivering FGF2 for wound healing than were PEG hydrogels. In vitro studies demonstrated that SBMA hydrogels could successfully prolong the release of FGF2, which effectively maintained the bioactivity of FGF2. Further in vivo investigation showed that SBMA hydrogels could efficiently accelerate wound regeneration by promoting granulation tissue formation, collagen deposition, cell proliferation and migration, reepithelialization and angiogenesis. All results validated that SBMA hydrogels were promising substituents of PEG hydrogels for delivering FGF2 for wound regeneration.
中文翻译：
两性离子水凝胶用于持续释放生长因子以促进伤口愈合
生长因子 (GFs) 因其对伤口愈合的治疗作用而广为人知。由于其脆弱的生物稳定性，生物材料载体通常用于传递 GFs 以保持其生物活性。在载体中，PEG水凝胶应用最为广泛。但 GFs 的不受控制的释放及其免疫原性极大地阻碍了 PEG 水凝胶作为 GFs 载体的应用。在此，开发了负载 FGF2 的两性离子磺基甜菜碱甲基丙烯酸酯 (SBMA) 水凝胶，结果表明这些水凝胶在递送 FGF2 以促进伤口愈合方面比 PEG 水凝胶更有效。体外研究表明，SBMA水凝胶可以成功延长FGF2的释放，有效地保持了FGF2的生物活性。进一步在体内研究表明，SBMA 水凝胶可通过促进肉芽组织形成、胶原沉积、细胞增殖和迁移、再上皮化和血管生成来有效加速伤口再生。所有结果均证实 SBMA 水凝胶是 PEG 水凝胶的有前途的替代物，可用于递送 FGF2 用于伤口再生。
更新日期：2020-12-16
中文翻译：
两性离子水凝胶用于持续释放生长因子以促进伤口愈合
生长因子 (GFs) 因其对伤口愈合的治疗作用而广为人知。由于其脆弱的生物稳定性，生物材料载体通常用于传递 GFs 以保持其生物活性。在载体中，PEG水凝胶应用最为广泛。但 GFs 的不受控制的释放及其免疫原性极大地阻碍了 PEG 水凝胶作为 GFs 载体的应用。在此，开发了负载 FGF2 的两性离子磺基甜菜碱甲基丙烯酸酯 (SBMA) 水凝胶，结果表明这些水凝胶在递送 FGF2 以促进伤口愈合方面比 PEG 水凝胶更有效。体外研究表明，SBMA水凝胶可以成功延长FGF2的释放，有效地保持了FGF2的生物活性。进一步在体内研究表明，SBMA 水凝胶可通过促进肉芽组织形成、胶原沉积、细胞增殖和迁移、再上皮化和血管生成来有效加速伤口再生。所有结果均证实 SBMA 水凝胶是 PEG 水凝胶的有前途的替代物，可用于递送 FGF2 用于伤口再生。
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