Near-infrared light-triggered nanobomb for in situ on-demand maximization of photothermal/photodynamic efficacy for cancer therapy,Biomaterials Science

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Near-infrared light-triggered nanobomb for in situ on-demand maximization of photothermal/photodynamic efficacy for cancer therapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-13 , DOI: 10.1039/d0bm01748e
Yan Liu _{1,

2,

3,

4,

5} , Jia Tian _{6,

7,

8,

9} , Yulei Fu _{6,

7,

8,

9} , Yingjie Yang _{1,

2,

3,

4,

5} , Mingmao Chen _{6,

7,

8,

9} , Qiqing Zhang _{6,

7,

8,

9}

Affiliation

Currently, the in situ on/off switch of PTT/PDT reagents for tumor treatment has evoked considerable interest in the field of cancer therapy. However, the actual PTT/PDT therapy efficacy in tumor treatment is largely restricted by the PTT/PDT reagents’ aggregation issues during their release from the hydrophobic carrier to the hydrophilic tumor microenvironment. Thus, it remains a challenge to break through the therapy barrier caused by the PTT/PDT agent aggregation and achieve substantial improvement of anticancer efficacy. In this work, we developed a novel near-infrared (NIR) light-responsive and gas bubble-generated liposomal nanobomb (Cy/Ce6/CO₂-Lip-FA) through the co-encapsulation of PTT/PDT reagents with gas precursor into the hydrophobic and hydrophilic regions of liposomes, respectively, in order to overcome the aggregation issues and substantially improve the synergistic PTT/PDT efficacy. Upon arrival at the tumor region, the PS phototoxicity of Cy/Ce6/CO₂-Lip-FA could be effectively switched on through CO₂ generation induced by the PTT effect of Cypate upon NIR irradiation. The gas bubble burst can remarkably suppress the aggregation of Cypate/Ce6 and extremely enhance the synergistic PTT/PDT efficacy. These results indicate that the proposed NIR-responsive and gas bubble-functionalized liposomal nanobomb is a highly promising platform for tumor treatment with better therapeutic efficacy.

中文翻译：

近红外光触发纳米炸弹用于癌症治疗的光热/光动力原位按需最大化

当前，用于肿瘤治疗的PTT / PDT试剂的原位开/关开关在癌症治疗领域引起了相当大的兴趣。但是，在肿瘤治疗中实际的PTT / PDT治疗功效在很大程度上受到PTT / PDT试剂从疏水性载体释放到亲水性肿瘤微环境的聚集问题的限制。因此，突破由PTT / PDT剂聚集引起的治疗障碍并实现抗癌功效的实质改善仍然是挑战。在这项工作中，我们开发了一种新型的近红外（NIR）光响应型和气泡产生的脂质体纳米炸弹（Cy / Ce6 / CO ₂-脂-FA）通过将PTT / PDT试剂与气体前体共包封分别进入脂质体的疏水和亲水区域，以克服聚集问题并显着提高PTT / PDT协同增效作用。到达肿瘤区域后，可以通过Cypate在NIR照射下的PTT效应诱导的CO ₂产生，有效地激活Cy / Ce6 / CO ₂ -Lip-FA的PS光毒性。气泡破裂可以显着抑制Cypate / Ce6的聚集并极大地增强PTT / PDT的协同功效。这些结果表明，拟议的近红外响应和气泡功能化的脂质体纳米炸弹是具有良好治疗效果的高度有前景的肿瘤治疗平台。

更新日期：2020-12-16

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