Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition typically targeting the axillary and anogenital regions of the body. The massive inflammatory cell infiltrate produced in this cryptogenic condition has led investigators in the attempt to link particular inflammatory cell fractions and cytokines to disease development, and ultimately to disease treatment. This study qualitatively and quantitatively analyzes the white blood cell fractions of macrophages, B-lymphocytes, T-lymphocytes, plasma cells, and granulocytes in 104 HS lesions on formalin-fixed paraffin-embedded tissues using immunohistochemistry (IHC). Four dermis-associated epithelial categories were investigated from persons with HS: 15 unaffected HS skin (US), 19 distended but unruptured follicle epithelium (UF), 62 migrating stratified squamous epithelium (MSSE) from ruptured follicles, and 35 degraded migrating epithelial sheets (DMES). In addition, 27 control skin (CS) from persons without HS were evaluated. Analysis of cell counts indicated that non-migratory dermal epithelium (CS, US, and UF) stimulated very little inflammatory response. However, contrary to previous studies which indicated macrophages to be the chief inflammatory cell in HS, this study showed that plasma cells were the primary cell type present in early-stage HS lesions (MSSE), whereas granulocytes were the major cell population seen in late-stage HS lesions (DMES):

化脓性汗腺炎 (HS) 是一种慢性炎症性皮肤病，通常针对身体的腋窝和肛门生殖器区域。在这种隐源性疾病中产生的大量炎性细胞浸润导致研究人员试图将特定的炎性细胞部分和细胞因子与疾病发展联系起来，并最终与疾病治疗联系起来。本研究使用免疫组织化学 (IHC) 定性和定量分析福尔马林固定石蜡包埋组织上 104 个 HS 病变中巨噬细胞、B 淋巴细胞、T 淋巴细胞、浆细胞和粒细胞的白细胞部分。研究了 HS 患者的四种真皮相关上皮类别：15 种未受影响的 HS 皮肤（美国），19 种扩张但未破裂的毛囊上皮（UF），62 个来自破裂滤泡的迁移复层鳞状上皮 (MSSE)，以及 35 个退化的迁移上皮层 (DMES)。此外，还评估了来自没有 HS 的人的 27 个对照皮肤 (CS)。细胞计数分析表明，非迁移性真皮上皮（CS、US ​​和 UF）刺激的炎症反应非常少。然而，与先前的研究表明巨噬细胞是 HS 的主要炎症细胞相反，本研究表明浆细胞是早期 HS 病变 (MSSE) 中存在的主要细胞类型，而粒细胞是晚期可见的主要细胞群。 -阶段HS病变（DMES）：US 和 UF) 刺激的炎症反应非常少。然而，与先前的研究表明巨噬细胞是 HS 的主要炎症细胞相反，本研究表明浆细胞是早期 HS 病变 (MSSE) 中存在的主要细胞类型，而粒细胞是晚期可见的主要细胞群。 -阶段HS病变（DMES）：US 和 UF) 刺激的炎症反应非常少。然而，与先前的研究表明巨噬细胞是 HS 的主要炎症细胞相反，本研究表明浆细胞是早期 HS 病变 (MSSE) 中存在的主要细胞类型，而粒细胞是晚期可见的主要细胞群。 -阶段HS病变（DMES）：