Neuroinflammation and cytokine-dependent neurotoxicity appear to be major contributors to the neuropathology in Parkinson’s disease (PD). While pharmacological advancements have been a mainstay in the treatment of PD for decades, it is becoming increasingly clear that nonpharmacological approaches including traditional and nontraditional forms of exercise and physical rehabilitation can be critical adjunctive or even primary treatment avenues. Here, we provide an overview of preclinical and clinical research detailing the biological role of proinflammatory molecules in PD and how motor rehabilitation can be used to therapeutically modulate neuroinflammation, restore neural plasticity, and improve motor function in PD.

中文翻译：

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细胞因子、神经营养蛋白和运动康复诱导的帕金森病可塑性


神经炎症和细胞因子依赖性神经毒性似乎是帕金森病 (PD) 神经病理学的主要贡献者。虽然几十年来药理学的进步一直是帕金森病治疗的支柱，但越来越明显的是，包括传统和非传统形式的运动和身体康复在内的非药物方法可以成为重要的辅助甚至主要治疗途径。在这里，我们概述了临床前和临床研究，详细介绍了促炎分子在帕金森病中的生物学作用，以及运动康复如何用于治疗性调节神经炎症、恢复神经可塑性和改善帕金森病的运动功能。