Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.

中文翻译：

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COVID-19 患者的炎症相关临床和代谢结果

背景。严重急性呼吸系统综合症冠状病毒 2 (SARS-COV-2) 感染会引发与“细胞因子风暴”相关的炎症表现。客观。本研究的目的是评估循环白细胞介素 6 (IL-6) 水平和其他炎症标志物在 2019 年冠状病毒病 (COVID-19) 患者中对代谢功能和伴随临床并发症的作用。患者和方法. 共检查了 165 名确诊为 COVID-19 肺炎的患者的医学特征和炎症标志物，例如血液 IL-6、CRP、铁蛋白、LDH、中性粒细胞/淋巴细胞指数 (NLI)、D-二聚体和红细胞分布宽度。 RDW）。通过适当的因素和混杂变量调整了有关以电子方式收集的医疗数据的回归分析。结果. 血浆 IL-6 测定证明与住院天数、重症监护病房 (ICU) 入院率和死亡率具有一致的相关性。其他促炎变量也发现了类似的趋势，其中铁蛋白和 NLI 作为替代指标显示出显着的价值。高血糖和查尔森合并症指数评分与 SARS-COV-2 感染引起的炎症反应呈正相关。吸烟和饮酒等不健康的生活方式以及过度肥胖会影响筛查患者的炎症相关结果。结论. IL-6 和其他炎症生物标志物在 COVID-19 感染患者中伴随着较差的临床和代谢结果。IL-6 可能会产生一个合适的代理来对患者进行单独分类，以管理这种传染性大流行。