Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase, is a signal transduction molecule shared by the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) family and the TNFR superfamily. TRAF6 has a unique TRAF domain and RING finger domain that mediate intracellular signaling events. In the immune system, TRAF6-mediated signaling has been shown to be critical for the development, homeostasis, and activation of a variety of immune cells, including B cells, T cells, dendritic cells, and macrophages. Although the pathogenesis and etiology of autoimmune diseases and cancer are not fully understood, it is worth noting that existing studies have shown that TRAF6 is involved in the pathogenesis and development of a variety of these diseases. Herein, we reviewed the role of TRAF6 in certain immune cells, as well as the function and potential effect of TRAF6 in autoimmune diseases and cancer. Our review indicates that TRAF6 may be a novel target for autoimmune diseases and cancer.

中文翻译：

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TRAF6参与自身免疫性疾病和癌症的免疫调节的机制

E3泛素连接酶是肿瘤坏死因子（TNF）受体相关因子6（TRAF6），是白介素1受体（IL-1R）/ Toll样受体（TLR）家族和TNFR超家族共有的信号转导分子。TRAF6具有介导细胞内信号转导事件的独特TRAF域和RING指域。在免疫系统中，TRAF6介导的信号转导对于多种免疫细胞（包括B细胞，T细胞，树突状细胞和巨噬细胞）的发育，体内平衡和激活至关重要。尽管对自身免疫性疾病和癌症的发病机理和病因学尚未完全了解，但值得注意的是，现有研究表明TRAF6参与了多种此类疾病的发病和发展。在这里，我们回顾了TRAF6在某些免疫细胞中的作用，以及TRAF6在自身免疫性疾病和癌症中的功能和潜在作用。我们的综述表明TRAF6可能是自身免疫性疾病和癌症的新型靶标。