The aim of this review is to highlight how, in a syngeneic system, human mononuclear phagocytes respond to environments containing human adenovirus (HAdV) and soluble extracellular proteins that influence their innate immune response. Soluble extracellular proteins, including immunoglobulins, blood clotting factors, proteins of the complement system, and/or antimicrobial peptides (AMPs) can exert direct effects by binding to a virus capsid that modifies interactions with pattern recognition receptors and downstream signaling. In addition, the presence, generation, or secretion of extracellular proteins can indirectly influence the response to HAdVs via the activation and recruitment of cells at the site of infection.

中文翻译：

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腺病毒—细胞外蛋白相互作用及其对人单核吞噬细胞固有免疫反应的影响

这篇综述的目的是强调在同系系统中，人类单核吞噬细胞如何应对含有人类腺病毒（HAdV）和影响其先天免疫应答的可溶性细胞外蛋白的环境。可溶性细胞外蛋白，包括免疫球蛋白，凝血因子，补体系统蛋白和/或抗菌肽（AMPs），可通过结合病毒衣壳来发挥直接作用，所述衣壳可修饰与模式识别受体和下游信号传导的相互作用。此外，细胞外蛋白的存在，产生或分泌可通过在感染部位激活和募集细胞间接影响对HAdV的反应。