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Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology
Molecules ( IF 4.6 ) Pub Date : 2020-11-26 , DOI: 10.3390/molecules25235555
Bhupendra Koul 1 , Arvind Kumar 2 , Dhananjay Yadav 3 , Jun-O Jin 3, 4
Affiliation  

Bergenia (Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhizomes of B. ligulata. Bergenia species also possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic. This review provides explicit information on the traditional uses, phytochemistry, and pharmacological significance of the genus Bergenia. The extant literature concerned was systematically collected from various databases, weblinks, blogs, books, and theses to select 174 references for detailed analysis. To date, 152 chemical constituents have been identified and characterized from the genus Bergenia that belong to the chemical classes of polyphenols, phenolic-glycosides, lactones, quinones, sterols, tannins, terpenes, and others. B. crassifolia alone possesses 104 bioactive compounds. Meticulous pharmacological and phytochemical studies on Bergenia species and its conservation could yield more reliable compounds and products of pharmacological significance for better healthcare.

中文翻译:

岩白菜属:​​传统用途、植物化学和药理学

岩白菜属(虎耳草科)原产于中亚,包含 32 种已知物种。其中,九个具有药理学相关性。在印度传统医学体系(阿育吠陀)中,“Pashanabheda”(碎石剂)是从 B. ligulata 根茎中提取的精华药物配方。岩白菜属物种还具有多种其他生物活性,如利尿、抗糖尿病、镇咳、杀虫、抗炎、解热、抗缓激肽、抗病毒、抗菌、抗疟、保肝、抗溃疡、抗癌、抗氧化、抗肥胖和适应原。这篇综述提供了有关白菜属的传统用途、植物化学和药理学意义的明确信息。从各种数据库、链接、博客、书籍和论文中系统地收集了现有的相关文献,选出了 174 篇参考文献进行详细分析。迄今为止,已从岩白菜属中鉴定和表征了 152 种化学成分,它们属于多酚、酚苷、内酯、醌、甾醇、单宁、萜烯等化学类别。仅 B. crassifolia 就含有 104 种生物活性化合物。对岩白菜属物种及其保护进行细致的药理学和植物化学研究可以产生更可靠的化合物和具有药理学意义的产品,以改善医疗保健。
更新日期:2020-11-26
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