Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.

中文翻译：

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固体农药剂型的深共熔溶剂

深度共晶溶剂有助于配制用于水不溶性活性物质的固体农药剂型。通过将Amitraz粉末封装在基于尿素（32 wt％）和1,3-二甲基脲的低共熔混合物的低熔点基质中来证明。含有20 wt％活性物质的熔铸圆盘在水中的溶解导致细分散形式的Amitraz迅速释放。溶解后，粒度减小的数量级归因于阿米特拉斯在热的深共熔溶剂中的增溶作用以及随后沉淀为基质结晶时的独立相。