Pulmonary function testing (PFT) is an important component for evaluating the outcome of experimental rodent models of respiratory diseases. Respiratory inductance plethysmography (RIP) provides a noninvasive method of PFT requiring minimal cooperation. RIP measures work of breathing (WOB) indices including phase angle (Ф), percent rib cage (RC %), breaths per minute (BPM), and labored breathing index (LBI) on an iPad. The aim of this study was to evaluate the utility of a recently developed research instrument, pneuRIP, for evaluation of WOB indices in a developmental rat model. Sprague Dawley rats (2 months old) were commercially acquired and anaesthetised with isoflurane. The pneuRIP system uses two elastic bands: one band (RC) placed around the rib cage under the upper armpit and another band (AB) around the abdomen. The typical thoracoabdominal motion (TAM) plot showed the abdomen and rib cage motion in synchrony. The plots of phase angle and LBI as a function of data point number showed that values were within the range. The distribution for phase angle and LBI was within a narrow range. pneuRIP testing provided instantaneous PFT results. This study demonstrated the utility of RIP as a rapid, noninvasive approach for evaluating treatment interventions in the rodent model.

肺功能测试（PFT）是评估呼吸系统疾病啮齿动物实验模型结果的重要组成部分。呼吸电感体积描记法（RIP）提供了一种无创的PFT方法，需要最少的配合。RIP可测量iPad上的呼吸功（WOB）指数，包括相角（Ф），肋骨百分比（RC％），每分钟呼吸数（BPM）和劳动呼吸指数（LBI）。这项研究的目的是评估最近开发的研究工具pneu RIP在发育中的大鼠模型中评估WOB指数的实用性。商业购买Sprague Dawley大鼠（2个月大）并用异氟烷麻醉。该PNEURIP系统使用两个弹性带：一个弹性带（RC）置于上腋下的肋骨周围，另一个弹性带（AB）围绕腹部。典型的胸腹运动（TAM）图显示了腹部和肋骨运动同步。相角和LBI作为数据点数的函数图表明，该值在该范围内。相角和LBI的分布在窄范围内。pneu RIP测试提供了瞬时PFT结果。这项研究证明了RIP作为一种快速，无创的​​方法来评估啮齿动物模型中的治疗干预措施的实用性。