The canonical Hedgehog (Hh) signalling pathway is essential for vertebrate development and its uncontrolled activation is a common occurrence in human cancers. Hh signalling converges in the modification of a family of transcription factors, GLI1, GLI2 and GLI3, to orchestrate a cell type and context-specific transcriptional response. Despite binding to very similar responsive elements, the GLI family members can exert diverse and even opposing functions. A recent article by Tolosa et al. (Biochem. J. 477, 3131–3145, 2020) reveals an unexpected layer of complexity, through physical and functional interaction between GLI1 and GLI2. This commentary discusses the biological significance of the findings and incorporates them into an updated ‘GLI code'.

中文翻译：

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GLI代码的另一种形式

规范化的刺猬（Hh）信号通路对于脊椎动物的发育至关重要，其不受控制的激活是人类癌症中的常见现象。Hh信号转导在转录因子家族GLI1，GLI2和GLI3的修饰中趋于一致，以协调细胞类型和特定于上下文的转录反应。尽管绑定了非常相似的响应元素，但GLI家族成员仍可以发挥多样化甚至相反的功能。Tolosa等人的最新文章。（Biochem。J. 477，3131–3145，2020）通过GLI1和GLI2之间的物理和功能相互作用揭示了意想不到的复杂性层。该评论讨论了发现的生物学意义，并将其纳入了更新的“ GLI代码”中。