ABSTRACT

Circular RNA, typically generated from backsplicing reaction, is a class of single-stranded and covalently linked RNA. Although most circular RNAs are lowly expressed, some of them are able to accumulate to high levels and even exceed their cognate mRNAs due to their longer half-lives. Once produced in the nucleus, the majority of circular RNAs are exported to the cytoplasm for their proper functions or degradation. In this review, we will summarize the biogenesis and classification of circular RNAs and highlight the recent advances in our understanding of circular RNA nuclear export and degradation.

中文翻译：

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环状RNA生物学新进展：从核输出到降解

摘要

环状 RNA，通常由反向剪接反应产生，是一类单链共价连接的 RNA。尽管大多数环状 RNA 的表达量很低，但由于其较长的半衰期，它们中的一些能够积累到高水平，甚至超过它们的同源 mRNA。一旦在细胞核中产生，大多数环状 RNA 就会被输出到细胞质中以发挥其正常功能或降解。在这篇综述中，我们将总结环状 RNA 的生物发生和分类，并重点介绍我们对环状 RNA 核输出和降解的理解的最新进展。